Faculty Profile

Anand_Ganesan_img

BIOGRAPHICAL SKETCH

BIOGRAPHY

Dr. Ganesan was born in Parkridge, Illinois and moved to Southern California at a young age.   He graduated with a bachelor of arts degree from the University of California, Berkeley where he did research in the laboratory of Hiroshi Nikaido, studying maltose transport in E. coli.   After graduation, Dr. Ganesan entered the MSTP program at the Medical College of Wisconsin.   He completed his PhD in 1999, and his research work in Joseph T. Barbieri’s laboratory focused on characterizing the mechanism by which bacterial exotoxins modulate eukaryotic cellular signal transduction.   After completing his MD degree in 2001 and a medical internship, Anand entered the dermatology residency and physician scientist training program at UT Soutwestern Medical Center.   During his clinical rotations, he became interested in hyperpigmentary disorders and melanoma.    During his residency and postdoctoral fellowship, he pursued these research interests in the laboratory of Michael A. White, PhD, where he gained expertise in RNAi-based functional genomics.   Dr. Ganesan’s work has focused on utilizing RNAi-based functional genomics to define novel pathways that regulate melanin production and melanoma chemoresistance.   He maintains an active clinical practice focusing on patients with pigmentary disorders and skin cancer.   The ultimate goal of his research is to develop new therapies to treat melanoma and pigmentary disorders.

A. Education

1990-1994                    Bachelor of Arts, Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA

1994-1999                    PhD, Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI

1994-2001                   MD, Medical College of Wisconsin, Milwaukee, WI

2001-2002                  Internship in Internal Medicine, St. Mary’s Medical Center, Long Beach,CA

2002-2005                  Dermatology Residency, UT Southwestern Medical Center, Dallas, TX

2004-2006                  Physician Scientist Training Program Fellow, UT Southwestern Medical Center, Dallas, TX

B.    Positions and Honors

Positions

2001- 2002                  Internal Medicine Intern, St. Mary’s Medical Center, Long Beach, California

2002- 2005                  Dermatology Resident, UT Southwestern Medical Center, Dallas, Texas

2004-2006                   PSTP Fellow, UT Southwestern Medical Center, Dallas, Texas

2005-2006                   Assistant Clinical Instructor, UT Southwestern Medical Center, Dallas, Texas

2006-                             Assistant Professor, Dept of Dermatology, UC Irvine    Irvine, California

2007-                             Assistant Professor, Dept. of Biological Chemistry, UC Irvine   Irvine, California

2007- 2011                   Co-Director, Translational Working Group for Melanoma, UCI Cancer Center

Honors and Awards

1994                                 Honors Graduate, University of California Berkeley

2001                                Armand J. Quick Award: Excellence in Biochemistry, Medical College of Wisconsin

2004                               Physician Scientist Training Program, UT Southwestern Medical Center

2007                               SID/ESDR Collegiality Award Recipient

2010-present                America’s Best Doctors

Other Experience and Professional Memberships

2006-present               Member, Society for Investigative Dermatology

2006-present               Fellow, American Academy of Dermatology

2011-present               Member, Pan American Society for Pigment Cell Research

2011-present               Member, American Association for Cancer Research

2011                               Ad-hoc Reviewer, ZRG1 MOSS-D (12)

2012                              Mail Reviewer, ACTS study section

 

B.    Peer-reviewed Publications

1. Hall JA. Ganesan AK. Chen J. Nikaido H. Two modes of ligand binding in maltose-binding protein of Escherichia coli.  Functional significance in active transport. Journal of Biological Chemistry 272(28):17615 -22. 1997 Jul 11.

2. Ganesan AK. Frank DW. Misra RP. Schmidt G. Barbieri JT.    Pseudomonas  aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites. Journal of Biological Chemistry. 273(13):7332-7. 1998 Mar 27.

3. Ganesan AK. Mende-Mueller L. Selzer J. Barbieri JT. Pseudomonas aeruginosa exoenzyme S, a double ADP-ribosyltransferase, resembles vertebrate mono-ADP-ribosyltransferases. Journal of Biological    Chemistry. 274(14):9503-9. 1999 Apr

4. Ganesan AK. Vincent TS. Olson JC. Barbieri JT. Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange.  Journal of Biological Chemistry. 274(31):21823-9. 1999 Jul 30.

5. Ganesan AK. Kho Y. Kim SC. Chen Y. Zhao Y. White MA.  Broad spectrum identification of SUMO substrates in melanoma cells.  Proteomics. 2007 Jul 7(13):2216-21

6. Ganesan AK. Ho H, Bodemann B.  Petersen S. Aruri J. Koshy S. Richardson Z. Le LQ. Krasieva T. Roth MG. Farmer P. White MA. Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesis in Human Cells. PLoS Genet. 2008 Dec;4(12):e1000298

7. Milenkovic T. Memisevic V. Ganesan AK. Przulj NSystems-level Cancer Gene Identification from Protein Interaction Network Topology Applied to Melanogenesis-related Functional Genomics Data.  J R Soc Interface, 2009 Jul 22

8.  Ho H. Milenkovic T. Memisevic V. Aruri J. Przulj N. Ganesan AK. Protein Interaction Network Topology Uncovers Melanogenesis Regulatory Network Components Within Functional Genomics Datasets. BMC Syst Biol. 2010;4:84. PMCID: 2904735

9.  Ho H. Kapadia R. Al-Tahan S. Ahmad S. Ganesan AK. WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. J Biol Chem. 2011; 8;286(14):12509-23.

10. Ho H. Ganesan AK.  The Pleiotropic Roles of Autophagy Regulators in Melanogenesis. Pigment Cell Melanoma Res. 2011 Aug;24(4):595-60.

11. Ghasri P. Gattu S.  Saedi N. Ganesan A. Chemical leukoderma following application of transdermal methylphenidate patch. J Am Acad Dermatol. 2012 Jun;66(6):e237-8.

12. Ho, H. Aruri, J. Kapadia, R. Mehr, H. White MA. Ganesan AK.  RhoJ and Pak Kinases Regulate Melanoma Chemoresistance by Suppressing Pathways that Sense DNA Damage. Cancer Res. 2012 Sep 12.

13. Ho H. Hopkin AS. Kapadia R. Vasudeva P.  Schilling J. Ganesan AK.  RhoJ Modulates Melanoma Invasion by Altering Actin Cytoskeletal Dynamics.  Pigment Cell Melanoma Res.  2012 Dec 18

 

C.    Research Support

CURRENT

UC Irvine                                                                          Ganesan(PI)                      12/01/08-11/31/13

NIAMS                  Role: PI

Title: 1K08ARO56001-01A1  Aldehyde Dehydrogenase: A Novel Regulator of Melanin Biogenesis.

The major goal of this project is to determine the mechanism whereby aldehyde dehydrogenase regulates melanogenesis. 

UC Irvine                                                                          Ganesan(PI)                      07/01/11-06/30/15

ACS                       Role: PI

Title: 121540-RSG-11-128-01-CSMRhoJ- A Novel Regulator of Melanoma Invasion and Chemoresistance.

The major goal of this project is to determine how RhoJ, a novel regulator of melanoma chemoresistance identified in a genome-wide RNAi screen, regulates melanoma invasion and chemoresistance.

 

PENDING

UC Irvine                                                                                                                                                   Ganesan(PI)                                        12/01/12-11/30/17

NIAMS                              Role:PI

Title: 1R01AR060916-01A1   Phosphoinositide Signaling Regulates Melanogenesis.

The major goal of this project is to determine how phosphoinositides and phosphoinositide binding proteins regulate melanosome biogenesis.