WELOCME TO THE SEILER LAB WEBSITE –
Magdalene Seiler, PhD, is an Assistant Professor of Physical Medicine & Rehabilitation at UC Irvine. Her ofice and lab are located in the Sue and Bill Gross Stem Cell Research Center. Seiler has most recently received a $4.8 million grant from the California Institute of Regenerative Medicine (CIRM) to continue developing a stem cell-based therapy for a vision-robbing eye disease, retinitis pigmentosa. The therapy may also be applicable to macular degeneration. Dr. Seiler and her team are focused on pre-clinical animal studies, assay development, qualifications to support CMC, future clinical activities, and ultimately a Pre-IND filing for her project, Morphological and functional integration of stem cell derived retina organoid sheets into degenerating retina models. The ultimate goal of her project is determining a treatment based on transplanting sheets of stem-cell derived retina, called retina organoids, to the back of the eye. Advanced stages of this disease show irreversible loss of photoreceptors, the light-sensing cells in the back of the eye, and patients gradually go blind. The aim is to replace damaged photoreceptors with the hope of re-establishing neural circuitry within the eye
Since 1995, Seiler and her team have pursued promising research into the development and use of retinal sheet transplantation, using a unique patented implantation instrument and procedure which has demonstrated improvement in visual responses in four different retinal degeneration models.
Seiler received her PhD in 1985 from the Ludwig-Maximilians University in Munich, Germany, with a Graduate fellowship at the Max-Planck-Institute for Neurochemistry in Martinsried (supervisor Martin Schwab, PhD). Her thesis focused on the role of neurotrophic factors in the Central Nervous System. She continued with post-doctoral studies in Winston-Salem, NC and Boston, MA (Schepens Eye Research Institute), followed by a 10-year faculty appointment at the University of Louisville and four years as an Assistant Professor at the Doheny Eye Institute, Departments of Ophthalmology & Visual Sciences and Cell & Neurobiology at USC, Los Angeles. Seiler’s scientific career has concentrated on retinal transplantation, retinal degeneration models, retinal development, stem cells and neurotrophic factors. Along with her colleague, Robert Aramant PhD, she developed and refined a unique procedure of retinal sheet transplantation which has demonstrated improvement of visual responses in four different retinal degeneration models (RCS rats, rd mice, rhodopsin S334ter-3 and -5 rat models of fast and slow retinal degeneration). This lead to conducting Phase I and II clinical trials that showed visual improvement in RP and AMD patients. Seiler has published over 56 articles in peer-reviewed journals, including one “citation classic” and 20 reviews / book chapters.
Seiler Lab: June 7, 2018