DAY 1 – 9.27.19 (2:00-9:30 pm)
- 2:00 pm Registration opens
- 5:00-5:15 pm Opening remarks by members of the Organizing Committee
- 5:15-6:00 pm Keynote Lecture #1: Grando, Sergei (USA) “Non-neuronal acetylcholine: a historical overview” (35 min talk + 10 min discussion)
- 6:00-6:45 pm Poster session
- 7:30-9:30 pm Welcome reception
DAY 2 – 9.28.19 (7:00 am-9:30 pm)
Session #1: Connection of NNACh to Inflammation – 8:00 am-12:00 pm
Chairs: William Horsnell, Donald Hoover and Wouter de Jonge
- 8:00 am-8:50 am Keynote Lecture #2: Kawashima, Koichiro (Japan) “Roles of alpha7 nAChRs expressed on antigen presenting cells and CD4+ T cells in regulation of antigen-specific CD4+ T cell differentiation” (40 min talk + 10 min discussion)
- Invited talks (each presentation 15 min + Q&A = 20 min)
- 8:50-9:10 Radek, Katherine (USA) “Cholinergic regulation of skin antimicrobial responses in models of injury and infection”
- 9:10-9:30 Pavlov, Valentin (USA) “Neuronal and non-neuronal acetylcholine in relation to the inflammatory reflex”
- 9:30-9:50 Horsnell, William (UK) “Regulation of pulmonary immunity by innate lymphoid cell derived acetylcholine”
- 9:50-10:20 Coffee break
- 10:20-10:40 de Jonge, Wouter (The Netherlands) “Neuro-immunity in host defense in the gut; neuronal and non-neuronal sources of neurotransmitters”
- 10:40-11:00 Hoover, Donald (USA) “Cholinergic leukocytes in sepsis and at the neuroimmune junction in the spleen”
- 11:00-11:20 Wess, Jurgen (USA) “Drug-mediated augmentation of acetylcholine signaling in pancreatic beta-cells: potential clinical implications”
- 11:20-11:30 Richter, Katrin (Germany) “C-reactive protein induces metabotropic functions at monocytic nicotinic acetylcholine receptors that control ATP-mediated maturation of interleukin-1β”
- 11:30 am-12:00 pm Group Discussion
- Lunch 12-1 pm
Session #2: Connection of NNACh to Cancer and Cellular Pathology – 1-5 pm
Chairs: Michael McIntosh, Jogeshwar Mukherjee and Maria Elena Sales
- 1:00-1:50 pm Keynote Lecture #3: Wessler, Ignaz (Germany) “Cholinergic anti-inflammatory pathways: facts and queries” (40 min talk + 10 min discussion)
- Invited talks (each presentation 15 min + Q&A = 20 min)
- 1:50-2:10 Lyukmanova, Ekaterina (Russia) “Human three-finger proteins in defense from epithelial cancer progression”
- 2:10-2:30 Mukherjee, Jogeshwar (USA) “Nicotinic radioligands for early diagnosis of neurodegeneration and lung cancer”
- 2:30-2:50 Sales, Maria Elena (Argentina) “Metronomic therapy focused on cholinergic receptors to treat cancer. Are nicotinic receptors involved?”
- 2:50-3:20 Coffee break
- 3:20-3:40 Layer, Paul (Germany) “Cholinergic and possible non-enzymatic actions of cholinesterases in bone development”
- 3:40-4:00 McIntosh, Michael (USA) “Novel peptide antagonists of alpha9 nAChRs and neuropathic pain”
- 4:00-4:20 Spindel, Eliot (USA) “Cholinergic signaling and lung development: Overlapping non-neuronal pathways and regulation”
- 4:20-4:30 Damaj, Imad (USA) “Role of α7 nicotinic acetylcholine receptors in chemotherapy- induced peripheral neuropathy in mice”
- 4:30-5:00 pm Group Discussion
DAY 3 – 9.29.19 (7 am – 12 pm)
- Breakfast 7:00-8:00 am
- Session #3: Molecular aspects of NNACH in Norm and Disease – 8:00 am-12:00 pm
- Chairs: Veronika Grau, Marina Skok and Jurgen Wess
- 8:00-8:50 am Keynote Lecture #4: Kummer, Wolfgang (Germany) “Paracrine actions and cotransmitters of acetylcholine in epithelial chemosensory cells” (40 min talk + 10 min discussion):
- Invited talks (each presentation 15 min + Q&A = 20 min)
- 8:50-9:10 Prado, Marco (Canada) “The non-neuronal cardiac cholinergic system in health and disease”
- 9:10-9:30 Kakinuma, Yoshihiko (Japan) “Possibility for the cardiac non-neuronal ACh system to modulate extra-cardiac functions”
- 9:30-9:50 Marchot, Pascale (France) “Alpha/beta-hydrolase fold proteins: a structural motif with multiple variations and functions”
- 9:50 -10:20 Coffee break
- 10:20-10:40 Skok, Marina (Ukraine) “Intracellular nicotinic acetylcholine receptors: the new data and new challenges”
- 10:40-11:00 Grau, Veronika (Germany) “Control of ATP-induced IL-1β Secretion by canonical and noncanonical nicotinic agonists”
- 11:00-11:10 Islas, Leon (Mexico) “The non-neuronal cholinergic system is upregulated in experimental pulmonary tuberculosis”
- 11:10-11:20 Saw, Eng Leng (Japan) “In-vivo activation of cardiac non-neuronal cholinergic system alleviates diabetes-induced cardiac dysfunction”
- 11:20-11:50 am Group Discussion
- 11:50 am-12:00 pm Presentation of the “Best Poster” award, and closing remarks