For the most up-to-date list of publications, look at Google Scholar here.


  1. J.Y. Hsieh, M.T. Keating, T.D. Smith, V.S. Meli, E.L. Botvinick, W.F. Liu
    Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation 

    APL Bioeng 3 (2019) link

  2. M. Keating, M. Lim, Q. Hu, E. Botvinick
    Selective stiffening of fibrin hydrogels with micron resolution via photocrosslinking

    Acta Biomater (2019) PubMed


  1. J.A. Gelfand, R.M. Nazarian, S. Kashiwagi, T. Brauns, B. Martin, Y. Kimizuka, S. Korek, E. Botvinick, K. Elkins, L. Thomas, J. Locascio, B. Parry, K.M. Kelly, M.C. Poznansky
    A pilot clinical trial of a near-infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking

    FASEB J (2018) PubMed

  2. J. Hou, J. Williams, E.L. Botvinick, E.O. Potma, B.J. Tromberg
    Visualization of breast cancer metabolism using multimodal nonlinear optical microscopy of cellular lipids and redox state

    Cancer Res 78 (2018) PubMed

  3. A. Najdahmadi, J.R.T. Lakey, E. Botvinick
    Structural characteristics and diffusion coefficient of alginate hydrogels used for cell based drug delivery

    MRS Adv 1-10 (2018) link

  4. B.A. Juliar, M.T. Keating, Y.P. Kong, E.L. Botvinick, A.J. Putnam
    Sprouting angiogenesis induces significant mechanical heterogeneities and ECM stiffening across length scales in fibrin hydrogels
    Biomaterials 162 (2018) PubMed

  5. Y. Zhang, M. Alexander, S. Yang, Y. Bian, E. Botvinick, J.R.T. Lakey, A. Ozcan
    High-throughput screening of encapsulated islets using wide-field lens-free on-chip imaging

    ACS Photonics (2018) link

  6. A. Najdahmadi, J.R.T. Lakey, E. Botvinick
    Diffusion coefficient of alginate microcapsules used in pancreatic islet transplantation, a method to cure type 1 diabetes

    Proc. SPIE 10506, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XV, 105061D (2018) link

  7. T. Thorson, E. Botvinick, A. Mohraz
    Composite bijel-templated hydrogels for cell delivery

    ACS Biomater. 4 (2018) link


  1. M. Keating, A. Kurup, M. Alvarez-Elizondo, A.J. Levine, E. Botvinick
    Spatial distributions of pericellular stiffness in natural extracellular matrices are dependent on cell-mediated proteolysis and contractility

    Acta Biomater. 57 (2017) PubMed

  2. R.E. Gurlin, M.T. Keating, S. Li, J.R.T. Lakey, S. de Feraudy, B.S. Shergill, E.L. Botvinick
    Vascularization and innervation of slits within polydimethylsiloxane sheets in the subcutaneous space of athymic nude mice

    J. Tissue Eng. 8 (2017) 204173141769164. PubMed

  3. M. Romero-López, A.L. Trinh, A. Sobrino, M.M.S. Hatch, M.T. Keating, C. Fimbres, D.E. Lewis, P.D. Gershon, E.L. Botvinick, M. Digman, J.S. Lowengrub, C.C.W. Hughes
    Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth

    Biomaterials. 116 (2017) 118–129. PubMed

  4. J.Y. Hsieh, T.D. Smith, V.S. Meli, T.N. Tran, E.L. Botvinick, W.F. Liu
    Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen

    Acta Biomater. 47 (2017) 14–24. PubMed


  1. M. Wang, S.R. Ravindranath, M.K. Rahim, E.L. Botvinick, J.B. Haun
    Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions

    Langmuir. 32 (2016) 13124–13136. PubMed

  2. A.H. Fong, M. Romero-López, C.M. Heylman, M. Keating, D. Tran, A. Sobrino, A.Q. Tran, H.H. Pham, C. Fimbres, P.D. Gershon, E.L. Botvinick, S.C. George, C.C.W. Hughes
    Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Tissue Eng. Part A. 22 (2016) 1016–1025. PubMed

  3. J. Arulmoli, H.J. Wright, D.T.T. Phan, U. Sheth, R.A. Que, G.A. Botten, M. Keating, E.L. Botvinick, M.M. Pathak, T.I. Zarembinski, D.S. Yanni, O. V. Razorenova, C.C.W. Hughes, L.A. Flanagan
    Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering

    Acta Biomater. 43 (2016) 122–138. PubMed


  1. J.C. Luo, E.L. Botvinick, V. Venugopalan
    Reply to “Mechanism for microtsunami-induced intercellular mechanosignalling”

    Nat. Photonics. 9 (2015) 624–625. link 

  2. A. Kurup, S. Ravindranath, T. Tran, M. Keating, P. Gascard, L. Valdevit, T.D. Tlsty, E.L. Botvinick
    Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.

    Sci. Rep. 5 (2015) 15153. PubMed

  3. A.C. Brown; S.R. Baker; A.M. Douglas; M. Keating; M.B. Alvarez-Elizondo; E.L. Botvinick; M. Guthold; T.H. Barker
    Molecular interference of fibrin’s divalent polymerization mechanism enables modulation of multiscale material properties.

    Biomaterials. 49 27-36. PubMed

  4. T.J. Kim; C. Joo; J. Seong; R. Vafabakhsh; E.L. Botvinick; M.W. Berns; A.E. Palmer; N. Wang; T. Ha; E. Jakobsson; J. Sun; Y. Wang
    Distinct mechanisms regulating mechanical force-induced Ca²⁺ signals at the plasma membrane and the ER in human MSCs.

    Elife. 4 e04876. PubMed


  1. J. Weidling; S. Sameni; J.R.T. Lakey; E. Botvinick
    Method measuring oxygen tension and transport within subcutaneous devices.

    J Biomed Opt. 19 (8), 87006. PubMed

  2. J.L. Compton; J.C. Luo; H. Ma; E. Botvinick; V. Venugopalan
    High-throughput optical screening of cellular mechanotransduction

    Nature Photonics. (8), 710–715 . PubMed


  1. Y. Tang; G. Rowe; E.L. Botvinick; A. Kurup; A.J. Putnam; M. Seiki; V.M. Weaver; E.T. Keller; S. Goldstein; J. Dai; D. Begun; T. Saunders; S.J. Weiss
    MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis.

    Dev Cell. PubMed


  1. J. Weidling; S.O. Isikman; A. Greenbaum; A. Ozcan; E. Botvinick
    Lens-free computational imaging of capillary morphogenesis within three-dimensional substrates.

    J Biomed Opt. 17 (12), 126018. PubMed

  2. J. Zhou; M.B. Alvarez-Elizondo; E. Botvinick; S.C. George
    Adenosine A1 and Prostaglandin EP3 Receptors Mediate Global Airway Contraction Following Local Epithelial Injury.

    Am J Respir Cell Mol Biol. PubMed

  3. H.S. Alavi; V. Ruiz; T. Krasieva; E.L. Botvinick; A. Kheradvar
    Characterizing the Collagen Fiber Orientation in Pericardial Leaflets Under Mechanical Loading Conditions.

    Ann Biomed Eng. PubMed

  4. B. Shergill; L. Meloty-Kapella; A.A. Musse; G. Weinmaster; E. Botvinick
    Optical tweezers studies on notch: single-molecule interaction strength is independent of ligand endocytosis.

    Dev Cell. 22 (6), 1313-20. PubMed

  5. L. Meloty-Kapella; B. Shergill; J. Kuon; E. Botvinick; G. Weinmaster
    Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin.

    Dev Cell. 22 (6), 1299-312. PubMed

  6. S.G. Shreim; E. Steward; E.L. Botvinick
    Extending vaterite microviscometry to ex vivo blood vessels by serial calibration

    Biomedical Optics Express. 3 (1), 37-47. PubMed

  7. E. Kniazeva; J.W. Weidling; R. Singh; E.L. Botvinick; M.A. Digman; E. Gratton; A.J. Putnam
    Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D

    Integrative Biology. 4 (4), 431-439. PubMed


  1. J. Zhou; M.B. Alvarez-Elizondo; E. Botvinick; S.C. George
    Local small airway epithelial injury induces global smooth muscle contraction and airway constriction.

    J Appl Physiol. 112 (4), 627-37. PubMed

  2. M.A. Kotlarchyk; S.G. Shreim; M.B. Alvarez-Elizondo; L.C. Estrada; R. Singh; L. Valdevit; E. Kniazeva; E. Gratton; A.J. Putnam; E.L. Botvinick
    Concentration independent modulation of local micromechanics in a fibrin gel.

    PLoS One. 6 (5), e20201. PubMed

  3. D. Dyer; S. Shreim; S. Jayadev; V. Lew; E. Botvinick; M. Khine
    Sequential shrink photolithography for plastic microlens arrays.

    Appl Phys Lett. 99 (3), 34102-341023. PubMed

  4. S.M. Anderson; B. Shergill; Z.T. Barry; E. Manousiouthakis; T.T. Chen; E. Botvinick; M.O. Platt; L.M. Iruela-Arispe; T. Segura
    VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF.

    Integr Biol (Camb). 3 (9), 887-96. PubMed


  1. N.M. Wakida; E.L. Botvinick; J. Lin; M.W. Berns
    An intact centrosome is required for the maintenance of polarization during directional cell migration.

    PLoS One. 5 (12), e15462. PubMed

  2. M.A. Kotlarchyk; E.L. Botvinick; A.J. Putnam
    Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging.

    J Phys Condens Matter. 22 (19), 194121. PubMed


  1. C. Mattei; P.J. Wen; T.D. Nguyen-Huu; M. Alvarez; E. Benoit; A.J. Bourdelais; R.J. Lewis; D.G. Baden; J. Molgó; F.A. Meunier
    Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells.

    PLoS One. 3 (10), e3448. PubMed

  2. J.M. Nascimento; L.Z. Shi; S. Meyers; P. Gagneux; N.M. Loskutoff; E.L. Botvinick; M.W. Berns
    The use of optical tweezers to study sperm competition and motility in primates.

    J R Soc Interface. 5 (20), 297-302. PubMed

  3. M.B. Alvarez-Elizondo; R. Rodríguez-Masegosa; J.C. Gutiérrez-Vega
    Generation of Mathieu-Gauss modes with an axicon-based laser resonator.

    Opt Express. 16 (23), 18770-5. PubMed

  4. J.M. Nascimento; L.Z. Shi; J. Tam; C. Chandsawangbhuwana; B. Durrant; E.L. Botvinick; M.W. Berns
    Comparison of glycolysis and oxidative phosphorylation as energy sources for mammalian sperm motility, using the combination of fluorescence imaging, laser tweezers, and real-time automated tracking and trapping.

    J Cell Physiol. 217 (3), 745-51. PubMed

  5. J.M. Nascimento; L.Z. Shi; C. Chandsawangbhuwana; J. Tam; B. Durrant; E.L. Botvinick; M.W. Berns
    Use of laser tweezers to analyze sperm motility and mitochondrial membrane potential.

    J Biomed Opt. 13 (1), 014002. PubMed

  6. L.Z. Shi; J.M. Nascimento; C. Chandsawangbhuwana; E.L. Botvinick; M.W. Berns
    An automatic system to study sperm motility and energetics.

    Biomed Microdevices. 10 (4), 573-83. PubMed


  1. E.L. Botvinick; Y. Wang
    Laser tweezers in the study of mechanobiology in live cells.

    Methods Cell Biol. 82 497-523. PubMed

  2. E.L. Botvinick; J.V. Shah
    Laser-based measurements in cell biology.

    Methods Cell Biol. 82 81-109. PubMed

  3. B. Shao; L.Z. Shi; J.M. Nascimento; E.L. Botvinick; M. Ozkan; M.W. Berns; S.C. Esener
    High-throughput sorting and analysis of human sperm with a ring-shaped laser trap.

    Biomed Microdevices. 9 (3), 361-9. PubMed

  4. B. Shao; J.M. Nascimento; L.Z. Shi; E.L. Botvinick
    Automated motile cell capture and analysis with optical traps.

    Methods Cell Biol. 82 601-27. PubMed


  1. L.Z. Shi; J.M. Nascimento; M.W. Berns; E.L. Botvinick
    Computer-based tracking of single sperm.

    J Biomed Opt. 11 (5), 054009. PubMed

  2. B. Shao; S.C. Esener; J.M. Nascimento; M.W. Berns; E.L. Botvinick; M. Ozkan
    Size tunable three-dimensional annular laser trap based on axicons.

    Opt Lett. 31 (22), 3375-7. PubMed

  3. J.M. Nascimento; J.L. Nascimento; E.L. Botvinick; L.Z. Shi; B. Durrant; M.W. Berns
    Analysis of sperm motility using optical tweezers.

    J Biomed Opt. 11 (4), 044001. PubMed

  4. L.Z. Shi; J. Nascimento; C. Chandsawangbhuwana; M.W. Berns; E.L. Botvinick
    Real-time automated tracking and trapping system for sperm.

    Microsc Res Tech. 69 (11), 894-902. PubMed

  5. B. Shao; S.C. Esener; J.M. Nascimento; E.L. Botvinick; M.W. Berns
    Dynamically adjustable annular laser trapping based on axicons.

    Appl Opt. 45 (25), 6421-8. PubMed


  1. Y. Wang; E.L. Botvinick; Y. Zhao; M.W. Berns; S. Usami; R.Y. Tsien; S. Chien
    Visualizing the mechanical activation of Src.

    Nature. 434 (7036), 1040-5. PubMed

  2. E.L. Botvinick; M.W. Berns
    Internet-based robotic laser scissors and tweezers microscopy.

    Microsc Res Tech. 68 (2), 65-74. PubMed


  1. E.L. Botvinick; V. Venugopalan; J.V. Shah; L.H. Liaw; M.W. Berns
    Controlled ablation of microtubules using a picosecond laser.

    Biophys J. 87 (6), 4203-12. PubMed


  1. D.A. Gough; E.L. Botvinick
    Reservations on the use of error grid analysis for the validation of blood glucose assays.

    Diabetes Care. 20 (6), 1034-6. PubMed