Title: Regulation of adiponectin and lipid processing in obesity and metabolic disease
Abstract: Adipose tissue is emerging as a key endocrine organ that regulates energy homeostasis. Dysregulation of the energy homeostasis system manifests as obesity and is implicated in many diseases. Adiponectin, an adipokine secreted by adipose tissue, promotes the usage/breakdown of lipids in cells, helps maintain a favorable lipid profile in the blood, reduces insulin resistance, is anti-inflammatory and anti-atherogenic. High levels of adiponectin can mitigate metabolic disease (e.g. diabetes) and heart disease. However, blood adiponectin levels are inversely related to fat mass and BMI even though fat produces adiponectin. We don’t understand why and how this relationship exists – it’s almost as if the system promotes disease in obese conditions. Experimental studies hint at regulatory feedback of adiponectin, which may be context-dependent, but the target and means of regulation is unclear. To investigate this, we are developing an ODE model of adiponectin, lipids (adipose and peripheral compartments), and insulin. This project is in the early stages so I would love to hear your ideas, questions, and feedback.