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Multi-Modality Optical Molecular Imaging Lab

  1. F. Nouizi, J. Brooks, D. M. Zuro, S. K. Hui, G. Gulsen, Development of a Theranostic Preclinical Fluorescence Molecular Tomography/Cone Beam CT-Guided Irradiator Platform, Biomedical Optics Express, 13 (11), 6100-6112 (2022).
  2. F. Nouizi, H. Erkol, D. Nikkah, T.C. Kwong, G. Gulsen, Development of a preclinical CCD-based temperature modulated fluorescence tomography platform, Biomedical Optics Express, 13 (11), 5740-5752 (2022).
  3. F. Nouizi, J. Cho, M. Algarawi, C.S. Kim, G. Gulsen, Application of a wavelength-swept laser for spectrally resolved wide-field near-infrared fluorescence imaging, Optics Continuum 1(8), 1768-1776, (2022).
  4. A. Eresen, K. Zhou, C. Sun, J. Shangguan, B. Wang, L. Pan, S. Hu, Y. Pang, Z. Zhang, R.M.N. Tran, A.P Bhatia, F. Nouizi, N. Abi-Jaoudeh, V. Yaghmai, Z. Zhang, Early assessment of irreversible electroporation ablation outcomes by analyzing MRI texture: preclinical study in an animal model of liver tumor, American journal of translational research, 14 (8), 5541-5551, (2022).
  5. F. Nouizi, M. Algarawi, H. Erkol, A. Luk, G. Gulsen, Multiwavelength photo-magnetic imaging algorithm improved for direct chromophore concentration recovery using spectral constraints, Applied Optics 60 (35), 10855-10861, (2021).
  6. M. Algarawi, H. Erkol, A. Luk, S. Ha, M.B. Unlu, G. Gulsen, F. Nouizi, Multi-wavelength Photo-Magnetic Imaging System for Photothermal Therapy Guidance, Lasers in Surgery and Medicine, (2021).
  7. F. Nouizi, J. Brooks, D. M. Zuro, S. S. Madabushi, D. Moreira, M. Kortylewski, J. Froelich, L. M. Su, G. Gulsen, S. K. Hui, Automated in vivo Assessment of Vascular Response to Radiation using a Hybrid Theranostic X-ray Irradiator/Fluorescence Molecular Imaging System, IEEE Access 8(1), 93663-93670 (2020). 
  8. H. Erkol, Z. Yelken, M. Algarawi, G. Gulsen, F. Nouizi, Validation of a comprehensive analytical model for photothermal therapy planning in a layered medium with gold nanoparticles, International Journal of Heat and Mass Transfer, 163, 120438 (2020).
  9. M. Algarawi, H. Erkol, A. Luk, M.B. Unlu, G. Gulsen, F. Nouizi, Resolving tissue chromophore concentration at MRI resolution using multi-wavelength Photo-Magnetic Imaging, Biomedical Optics Express, 11(8), 4244-4254 (2020).
  10. E. Mikhaylova#, J. Brooks#, D. Zuro#, F. Nouizi#, M. Kujawski, S. S. Madabushi, J. Qi, M. Zhang, J. Chea, E. K. Poku, N. Bowles, J. Y. C. Wong, J. E. Shively, P. J. Yazaki, G. Gulsen, S. R. Cherry, S. Hui, “Prototype Small-Animal PET-CT Imaging System for Image-guided Radiation Therapy”, IEEE Access 7, 143207-143216 (2019). (# multiple 1st Author)
  11. Aude I Segaliny, Jason L Cheng, Henry P Farhoodi, Michael Toledano, Chih Chun Yu, Beatrice Tierra, Leanne Hildebrand, Linan Liu, Michael J Liao, Jaedu Cho, Dongxu Liu, Lizhi Sun, Gultekin Gulsen, Min-Ying Su, Robert L Sah, Weian Zhaom, Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells, EBioMedicine 45, 39-57, (2019)
  12. N Uluc, MB Unlu, G Gulsen, H Erkol, Extended photoacoustic transport model for characterization of red blood cell morphology in microchannel flow, Biomedical Optics Express 9 (6), 2785-2809, (2018)
  13. F. Nouizi, T. C. Kwong, J. Ruiz, J. Cho, Y. Chan, K. Ikemura, H. Erkol, U. Sampathkumaran, G. Gulsen, A thermo-sensitive fluorescent agent based method for excitation light leakage rejection for fluorescence molecular tomography, Physics in medicine and biology, 64(3), 035007 -035018 (2018).
  14. H Jang, G Lim, KS Hong, J Cho, G Gulsen, CS Kim, Effect of shot noise on simultaneous sensing in frequency division multiplexed diffuse optical tomographic imaging process, Sensors 17 (12), 2752, (2017)
  15. A. T. Luk, F. Nouizi, H. Erkol, M. B. Unlu, G. Gulsen, ex vivo Validation of Photo-Magnetic Imaging, Optics Letters, 42 (20), 4171-4174 (2017).
  16. T.C. Kwong, F. Nouizi, J. Cho, Y. Lin, U. Sampathkumaran, G. Gulsen, Feasibility study of high spatial resolution multimodality fluorescence tomography in ex vivo biological tissue, Applied Optics, 56(28), 7886-7891 (2017).
  17. J. Ruiz, F. Nouizi, J. Cho, J. Zheng, Y. Li, J. Chen, M. Su, G. Gulsen, Breast density quantification using structured-light based diffuse optical tomography simulations, Applied Optics, 56(25), 7146-7157 (2017). 
  18. Jie Zheng, Kristopher L Anderson, Stephanie L Leal, Avgusta Shestyuk, Gultekin Gulsen, Lilit Mnatsakanyan, Sumeet Vadera, Frank PK Hsu, Michael A Yassa, Robert T Knight, Jack J Lin, Amygdala-hippocampal dynamics during salient information processing, Nature communications 8 (1), 14413, (2017)
  19. T.C. Kwong, F. Nouizi, Y. Lin, J. Cho, Y. Zhu, U. Sampathkumaran, G. Gulsen, Experimental Evaluation of the Resolution and Quantitative Accuracy of Temperature-Modulated Fluorescence Tomography, Applied Optics, 56(3), 521-529 (2017).
  20. F. Nouizi, H. Erkol, A. Luk, M. Marks, M.B. Unlu, G. Gulsen, An accelerated photo-magnetic imaging reconstruction algorithm based on an analytical forward solution and a fast Jacobian assembly method, Physics in Medicine and Biology, 61(20), 7448 (2016).
  21. F. Nouizi, H. Erkol, A. Luk, M.B. Unlu, G. Gulsen, Real-time photo-magnetic imaging. Biomedical Optics Express, 7(10), 3899-3904 (2016).
  22. F. Nouizi, A. Luk, D. Thayer, Y. Lin, S. Ha, G. Gulsen, Experimental validation of a high-resolution diffuse optical imaging modality: photomagnetic imaging, Journal of biomedical optics, 21(1), 016009-016009 (2016).
  23. H. Erkol, F. Nouizi, A. Luk, M.B. Unlu, G. Gulsen, Comprehensive analytical model for CW laser induced heat in turbid media, Optics express, 23(24), 31069-31084 (2015).
  24. F. Nouizi, T.C. Kwong, J. Cho, Y. Lin, U. Sampathkumaran, G. Gulsen, Implementation of a new scanning method for high-resolution fluorescence tomography using thermo-sensitive fluorescent agents, Optics letters, 40(21), 4991-4994 (2015).
  25. Y. Lin, F. Nouizi, T.C. Kwong, G. Gulsen, Simulation-Based Evaluation of the Resolution and Quantitative Accuracy of Temperature-Modulated Fluorescence Tomography, Applied optics 54 (25), 7612-7621 (2015).
  26. H. Erkol, F. Nouizi, M.B. Unlu, G. Gulsen, An extended analytical approach for diffuse optical imaging, Physics in medicine and biology, 60 (13), 5103 (2015).
    1. F Nouizi, H Erkol, D Nikkhah, TC Kwong, G Gulsen, A continuous line scanning method for fast temperature modulated fluorescence tomography, Optical Tomography and Spectroscopy of Tissue XV, PC123760Q, (2023)
    2. F Nouizi, M Algarawi, H Erkol, G Gulsen, Multiwavelength photo-magnetic imaging: a novel high-resolution optical molecular imaging modality, Multimodal Biomedical Imaging XVIII, PC1237109, (2023)
    3. F Nouizi, A Eresen, Z Zhang, V Yaghmai, G Gulsen, Longitudinal Monitoring of Irreversible Electroporation Outcomes Using Hybrid Functional/Structural Variations of HCC Microenvironment, Journal of Vascular and Interventional Radiology 34 (3), S7, (2023)
    4. A Eresen, Z Zhang, Z Yu, N Abi-Jaoudeh, F Nouizi, V Yaghmai, MRI Monitoring Transcatheter Intraportal Vein Delivery of Clinically Applicable-Magnetic Labeled Natural Killer Cells for Liver Tumor Adoptive immunotherapy, Journal of Vascular and Interventional Radiology 34 (3), S112, (2023)
    5. Z Yu, Z Zhang, J Tan, Q Hou, F Nouizi, V Yaghmai, A Eresen, Quantitative MRI Texture Analysis for Evaluating Treatment Response Following Irreversible Electroporation Ablation in Hepatocellular Carcinoma, Journal of Vascular and Interventional Radiology 34 (3), S82, (2023)
    6. F. Nouizi, A. Moy, W. Moy, G. Gulsen, Comparison of Fluorescence and Bioluminescence Imaging Using iRFP & Luciferase Labeled 4T1 Breast Cancer Model, Optica BioMed, (2022).
    7. F. Nouizi, J. Brooks, D. M. Zuro, S. K. Hui, G. Gulsen, Theranostic Fluorescence Tomography -Guided Small Animal X-ray Irradiator Platform: System Development and Validation, Optica BioMed, (2022).
    8. D. Nikkhah, F. Nouizi, R. Hurtado, P. Tabatabaei, G. Gulsen, Temperature Modulated Fluorescence Tomography Feasibility Using an Intensified CCD Camera, Optica BioMed, (2022).
    9. Y. Zhang, F. Nouizi, N. Lang, X. Xing, Y. Chen, Q. Wang, E. Zhang, H. Yuan, K. Nie, L. M. Su, Deep Learning Approaches Using Convolutional Neural Networks to Generate Synthetic CT from Spinal MRI for Radiotherapy Planning, ISMRM, 3414, (2022).
    10. A. Eresen, C. Sun, K. Zhou, J. Shangguan, B. Wang, L. Pan, S. Hu, R.M.N. Tran, Q. Ma, J. Yang, F. Nouizi, N. Abi-Jaoudeh, Z. Zhang, and V. Yaghmai, Correlation of Histological Tumor Biomarkers with Multivariable MRI Texture Model, Society of Interventional Radiology Annual Conference (2022).
    11. F. Nouizi, M. Algarawi, H. Erkol, A. Luk, G. Gulsen, Photo‐magnetic imaging: a new functional imaging modality for more accurate photothermal therapy planning, SPIE Bios 1194006 (2022).
    12. F. Nouizi, J. Brooks, D. Zurro, S. K. Hui, G. Gulsen, Implementation of a combined theranostic x-ray irradiator/fluorescence imaging system for automatic assessment of tumor vascular response to radiation therapy, SPIE Bios 1194405 (2022).
    13. M. Algarawi, F. Nouizi, A. Luk, H. Erkol, M. Almudhry, M. B. Unlu, S. Ha, G. Gulsen, Experimental validation of a multiple wavelength Photo-Magnetic Imaging system, OSA BioMed, STh3D.3 (2020).
    14. M. Algarawi, A. Luk, H. Erkol, M. Almudhry, M. B. Unlu, G. Gulsen, F. Nouizi, Reconstruction chromophore concentration directly by PhotoMagnetic Imaging: simulation study, OSA BioMed, JTu3A.15 (2020).
    15. M. Mehrabi, F Nouizi, M. Algarawi, T. C. Kwong, H. Erkol, U. Sampathkumaran, and G. Gulsen, CCD-based temperature modulated fluorescence tomography, SPIE BiOS, 10874, 108740Y (2019)
    16. M. Algarawi, F. Nouizi, A. Luk, M. Mehrabi, H. Erkol, S. Ha, M. B. Unlu, G. Gulsen, High-resolution chromophore concentration recovery using multi-wavelength photo-magnetic imaging, SPIE BiOS, 10871, 108710F (2019).
    17. K. Ikemura, F. Nouizi, Convolutional Neural Network to Classify Histological Images: Idea on How to Increase Sample Size, Laboratory Investigation, 98 (Nature Pathology, Vol 31, suppl 1), (2018).
    18. F. Nouizi, H. Erkol, M. Algarawi, M. Mehrabi, G. Gulsen, Multi-wavelengths Photo Magnetic Imaging, OSA BioMed, JW3A. 45 (2018).
    19. H. Erkol. F. Nouizi, M. Mehrabi, M. Algarawi, B. Unlu, G. Gulsen, A Comprehensive Analytical Based Computational Technique for Laser Induced Heat in a Gold Nano-particle Embedded Turbid Medium, OSA BioMed, JTh3A. 16 (2018).
    20. P.A. Lo, J. Cho, F. Nouizi, H.K. Chiang, G. Gulsen, Multispectral fluorescence diffuse optical tomography, SPIE BiOS, 10056, 100560Z-1 (2017).
    21. F. Nouizi, A. Luk, M. Marks, J. Cho, S. Ha, H. Erkol, J. Kwong, G. Gulsen, Multi-wavelength photomagnetic imaging for breast cancer, Invited talk at SPIE BiOS, 10059-40 (2017).
    22. H. Erkol, F. Nouizi, A. Luk, M.B. Unlu, G. Gulsen, A new analytical approach for heat generation in tissue due to laser excitation, SPIE BiOS, 97060L (2016).
    23. F. Nouizi, H. Erkol, A. Luk, Y. Lin, G. Gulsen, Analytical Photo Magnetic Imaging, OSA BioMed, OW4D-7 (2016).
    24. H. Erkol, F. Nouizi, A. Luk, M.B. Unlu, G. Gulsen, An Analytical Approach for Temperature Distribution in Tissue, OSA BioMed, JW3A-12 (2016).
    25. T.C. Kwong, P.A. Lo, J. Cho, F. Nouizi, H.K. Chiang, C.S. Kim, G. Gulsen, Multi-wavelength fluorescence tomography. SPIE BiOS, 97001A (2016).
    26. A.T. Luk, F. Nouizi, M. Marks, T. Kart, G. Gulsen, Monitoring gold nanoparticle distribution with high resolution using photo-magnetic imaging, SPIE BiOS, 97060M (2016).
    27. T.C. Kwong, F. Nouizi, Y. Lin, Y. Zhu, U. Sampathkumaran, G. Gulsen, Thermal outlining using focused ultrasound (TOFU) with reversible temperature sensitive fluorescent probes, SPIE BiOS, 97010 (2016).
    28. J. Kwong, F. Nouizi, J. Cho, J. Zheng, Y. Li, J.H. Chen, M.Y. Su, G. Gulsen, Diffuse optical tomography with structured-light patterns to quantify breast density, SPIE BiOS, 968942 (2016).
    29. J. Zheng, F. Nouizi, J. Cho, J. Kwong, G. Gulsen, High resolution 3D fluorescence tomography using ballistic photons, SPIE BiOS, 93191V-93191V-5 (2015).
    30. F. Nouizi, T.C. Kwong, J. Kwong, J. Cho, Y. Chan, U. Sampathkumaran, Y. Zhu, M.M. Alam, G. Gulsen, Excitation light leakage suppression using temperature sensitive fluorescent agents, SPIE BiOS, 93190Y-93190Y-5 (2015).
    31. T.C. Kwong, F. Nouizi, U. Sampathkumaran, Y. Zhu, M.M. Alam, G. Gulsen, Activatable thermo-sensitive ICG encapsulated pluronic nanocapsules for temperature sensitive fluorescence tomography, SPIE BiOS, 93390C-6 (2015).
    32. J. Kwong, F. Nouizi, J. Cho, J. Zheng, Y. Li, J. Chen, M.Y. Su, G. Gulsen , Diffuse optical imaging of the breast using structured-light, SPIE BiOS, 93190K-5 (2015).
    33. F. Nouizi, J. Cho, A. Luk, E. Anashkin, P. Stepanov, V. Zavarzin, I. Weinberg, M.Y. Su, G. Gulsen, O. Nalcioglu, Hybrid PEM/MRI, a new approach for high resolution breast imaging, ISMRM 23rd Annual Meeting & Exhibition, Toronto, Ontario, Canada ( 2015).
    34. A. Luk, S. Ha, F. Nouizi, D. Thayer, Y. Lin, G. Gulsen , A true multi-modality approach for high resolution optical imaging: photo-magnetic imaging, SPIE BiOS, 89370G-7 (2014).
    35. T.C. Kwong, F. Nouizi, Y. Lin, R. Rajyaguru, T. Nguyen, L. Alptekin, U. Sampathkumaran, Y. Zhu, S. Ahmed, G. Gulsen, Validation of temperature-modulated fluorescence tomography in vivo, SPIE BiOS, 89370H-7 (2014).
    36. J. Kwong, F. Nouizi, Y. Li, J.H. Chen, M.Y. Su, G. Gulsen , Simulation of optical breast density measurements using structured light illumination, SPIE BiOS, 893717-8 (2014).
    37. F. Nouizi, T. Kwong, Y. Lin, U. Sampathkumaran, A. Shaaz, and G. Gulsen, A combined HIFU-Fluorescence Tomography high-resolution imaging technique using temperature-modulated thermodots, OSA Optics in the life science, JW3B.8 (2013).
    38. T. C. Kwong, F. Nouizi, Y. Lin, U. Sampathkumaran, A. Shaaz, G. Gulsen, Temperature-modulated fluorescence tomography: modulating tissue temperature using HIFU for high-resolution in vivo fluorescence tomography, SPIE BiOS, 857405-8 (2013).
    39. A. Luk, D. Thayer, Y. Lin, F. Nouizi, H. Gao, G. Gulsen, A novel high-resolution optical imaging modality: photo-magnetic imaging, SPIE BiOS, 857404 (2013).
    40. T.C. Kwong, F. Nouizi, Y. Lin, U. Sampathkumaran, S. Ahmed, G. Gulsen, Temperature-modulated fluorescence tomography: modulating tissue temperature using HIFU for high-resolution in vivo fluorescence tomography. SPIE BiOS, 857405 (2013).
    1. “An Apparatus and Method for Quantitative Noncontact In Vivo Fluorescence Tomography Using a Priori Information”- Application # 61430036
    2. “Method and Apparatus for Photomagnetic Imaging”, – Application # 61550258
    3. “Temperature-modulated Fluorescence Tomography”- Application Number # 61577624
    4. “Multi-modal image-guided radiation system” – US Patent 11,607,184, (2023)