Since its founding in 2014, the Chemical and Structural Biology (CSB) Training Program at UC Irvine has supported a number of publications through the financial support of CSB fellows. Below is a continuously updated list of publications that have been made possible by the CSB program (CSB fellow authors in bold). If you notice an article that is missing and should be added to the list, please contact the CSB program to have it added to the publication list. (Co-first author publications are designated by “and” between the coauthors below).
2017
Jones KA, Porterfield WB, Rathbun CM, McCutcheon DC, Paley MA, Prescher JA (2017). “Orthogonal Luciferase–Luciferin Pairs for Bioluminescence Imaging.” JACS 139: 2351-2358.
Steinhardt RC, Rathbun CM, Krull BT, Yu JM, Yang Y, Nguyen BD, Kwon J, McCutcheon DC, Jones KA, Furche F, Prescher JA (2017). “Brominated Luciferins Are Versatile Bioluminescent Probes.” ChemBioChem 18: 96-100.
2016
O’Brien J, Lee SH, Onogi S, Shea KJ (2016). “Engineering the protein corona of a synthetic polymer nanoparticle for broad-spectrum sequestration and neutralization of venomous biomacromolecules.” JACS in press.
Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC, Challis GL (2016). “A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.” Nature Communications 7: 13609.
Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL (2016). “Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.” Biochemistry 55: 5587-5594.
Hollingsworth SA and Lewis MC, and Karplus PA. (2016). “Beyond basins: φ,ψ preferences of a residue depend heavily on the φ,ψ values of its neighbors.” Protein Sci. 25: 1757-1762.
Nazarova LA, Ochoa RJ, Jones KA, Morrissette NS, Prescher JA (2016). “Extracellular Toxoplasma gondii tachyzoites metabolize and incorporate unnatural sugars into cellular proteins.” Microbes and Infection 18: 199-210.
Yu C, Huszagh A, Viner R, Novitsky EJ, Rychnovsky SD, Huang L (2016). “Developing a Multiplexed Quantitative Cross-linking Mass Spectrometry Platform for Comparative Structural Analysis of Protein Complexes.” Analytical Chemistry 88: 10301.
Hollingsworth SA and Batabyal D, Nguyen BD and Poulos TL. (2016). “Conformational selectivity in cytochrome P450 redox partner interactions.” PNAS. 113: 8723-8728.
Gutierrez CB, Yu C, Novitsky EJ, Huszagh AS, Rychnovsky SD, Huang L (2016). “Developing an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein–Protein Interactions.” Analytical Chemistry 88: 8315.
O’Brien J and Shea KJ. (2016). “Tuning the protein corona of hydrogel nanoparticles: the synthesis of abiotic protein and peptide affinity reagents.” Accounts of Chem. Res. In Press.
Salveson PJ, Spencer RK and Nowick JS. (2016). “X-ray crystallographic structure of oligomers formed by a toxic beta-hairpin derived from alpha-synuclein: trimers and higher-order oligomers.” JACS. 138: 4458-67.
Yu C, Mao H, Novitsky E, Rychnovsky SD, Zheng N, Huang L (2016). “Unraveling the Activation Mechanism of Cullin-RING Ubiquitin Ligases using Quantitative Cross-linking Mass Spectrometry.” The FASEB Journal 30: 595.6.
Hollingsworth SA and Holden JK, Li H and Poulos TL. (2016). “Elucidating nitric oxide synthase domain interactions by molecular dynamics.” Protein Sci. 25:374-382.
2015
Yu C, Mao H, Novitsky EJ, Tang X, Rychnovsky SD, Zheng N and Huang L. (2015). “Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.” Nature Comm. 6.
Burke MA, Kandur W, Novitsky EJ, Kaake RM, Yu C, Kao A, Vellucci D, Huang L and Rychnovsky SD. (2015). “Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry.” Organic Biomol Chem. 13: 5030-7.
Fields JB and Hollingsworth SA, Chreifi G, Heyden M, Arce AP, Magaña-Garcia HI, Poulos TL and Tobias DJ. (2015). “’Bind and Crawl’ Association mechanism of Leishmania major peroxidase and cytochrome c revealed by Brownian and molecular dynamics simulations.” Biochemistry. 54:7272-82.
Porterfield WB, Jones KA, McCutcheon DC and Prescher JA. (2015). “A ‘caged’ luciferin for imaging cell-cell contacts.” JACS. 137: 8656-9.
Chreifi G, Hollingsworth SA, Li H, Tripathi S, Arce AP, Magaña-Garcia HI and Poulos TL. (2015). “Enzymatic mechanism of Leishmania major peroxidase and the critical role of specific ionic interactions.” Biochemistry. 54: 3328-3336.
Jones KA, Li DJ, Hui E, Sellmyer MA, and Prescher JA. (2015). “Visualizing cell proximity with genetically encoded bioluminescent reporters.” ACS Chem Bio. 10: 933-8.
Hollingsworth SA and Poulos TL. (2015). “Molecular dynamics of the P450cam-Pdx complex reveals complex stability and novel interface contacts.” Protein Sci. 24: 49-57.
2014
Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB and Poulos TL. (2014). “Structure-based design of bacterial nitric oxide synthase inhibitors.” J. Med Chem. 58: 994-1004.