Professor, Dermatology, School of Medicine
Professor, Biological Chemistry, School of Medicine
BIOGRAPHY
Dr. Ganesan was born in Parkridge, Illinois and moved to Southern California at a young age. He graduated with a bachelor of arts degree from the University of California, Berkeley where he did research in the laboratory of Hiroshi Nikaido, studying maltose transport in E. coli. After graduation, Dr. Ganesan entered the MSTP program at the Medical College of Wisconsin. He completed his PhD in 1999, and his research work in Joseph T. Barbieri’s laboratory focused on characterizing the mechanism by which bacterial exotoxins modulate eukaryotic cellular signal transduction. After completing his MD degree in 2001 and a medical internship, Anand entered the dermatology residency and physician scientist training program at UT Soutwestern Medical Center. During his clinical rotations, he became interested in hyperpigmentary disorders and melanoma. During his residency and postdoctoral fellowship, he pursued these research interests in the laboratory of Michael A. White, PhD, where he gained expertise in RNAi-based functional genomics. Dr. Ganesan’s work has focused on utilizing RNAi-based functional genomics to define novel pathways that regulate melanin production and melanoma chemoresistance. He maintains an active clinical practice focusing on patients with pigmentary disorders and skin cancer. The ultimate goal of his research is to develop new therapies to treat melanoma and pigmentary disorders.
A. Education
1990-1994 Bachelor of Arts, Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA
1994-1999 PhD, Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI
1994-2001 MD, Medical College of Wisconsin, Milwaukee, WI
2001-2002 Internship in Internal Medicine, St. Mary’s Medical Center, Long Beach,CA
2002-2005 Dermatology Residency, UT Southwestern Medical Center, Dallas, TX
2004-2006 Physician Scientist Training Program Fellow, UT Southwestern Medical Center, Dallas, TX
B. Positions and Honors
Positions
2001- 2002 Internal Medicine Intern, St. Mary’s Medical Center, Long Beach, California
2002- 2005 Dermatology Resident, UT Southwestern Medical Center, Dallas, Texas
2004-2006 PSTP Fellow, UT Southwestern Medical Center, Dallas, Texas
2005-2006 Assistant Clinical Instructor, UT Southwestern Medical Center, Dallas, Texas
2006- Assistant Professor, Dept of Dermatology, UC Irvine Irvine, California
2007- Assistant Professor, Dept. of Biological Chemistry, UC Irvine Irvine, California
2007- 2011 Co-Director, Translational Working Group for Melanoma, UCI Cancer Center
Honors and Awards
1994 Honors Graduate, University of California Berkeley
2001 Armand J. Quick Award: Excellence in Biochemistry, Medical College of Wisconsin
2004 Physician Scientist Training Program, UT Southwestern Medical Center
2007 SID/ESDR Collegiality Award Recipient
2010-present America’s Best Doctors
Other Experience and Professional Memberships
2006-present Member, Society for Investigative Dermatology
2006-present Fellow, American Academy of Dermatology
2011-present Member, Pan American Society for Pigment Cell Research
2011-present Member, American Association for Cancer Research
2011 Ad-hoc Reviewer, ZRG1 MOSS-D (12)
2012 Mail Reviewer, ACTS study section
B. Peer-reviewed Publications
1. Hall JA. Ganesan AK. Chen J. Nikaido H. Two modes of ligand binding in maltose-binding protein of Escherichia coli. Functional significance in active transport. Journal of Biological Chemistry 272(28):17615 -22. 1997 Jul 11.
2. Ganesan AK. Frank DW. Misra RP. Schmidt G. Barbieri JT. Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites. Journal of Biological Chemistry. 273(13):7332-7. 1998 Mar 27.
3. Ganesan AK. Mende-Mueller L. Selzer J. Barbieri JT. Pseudomonas aeruginosa exoenzyme S, a double ADP-ribosyltransferase, resembles vertebrate mono-ADP-ribosyltransferases. Journal of Biological Chemistry. 274(14):9503-9. 1999 Apr
4. Ganesan AK. Vincent TS. Olson JC. Barbieri JT. Pseudomonas aeruginosa exoenzyme S disrupts Ras-mediated signal transduction by inhibiting guanine nucleotide exchange factor-catalyzed nucleotide exchange. Journal of Biological Chemistry. 274(31):21823-9. 1999 Jul 30.
5. Ganesan AK. Kho Y. Kim SC. Chen Y. Zhao Y. White MA. Broad spectrum identification of SUMO substrates in melanoma cells. Proteomics. 2007 Jul 7(13):2216-21
6. Ganesan AK. Ho H, Bodemann B. Petersen S. Aruri J. Koshy S. Richardson Z. Le LQ. Krasieva T. Roth MG. Farmer P. White MA. Genome-Wide siRNA-Based Functional Genomics of Pigmentation Identifies Novel Genes and Pathways That Impact Melanogenesis in Human Cells. PLoS Genet. 2008 Dec;4(12):e1000298
7. Milenkovic T. Memisevic V. Ganesan AK. Przulj N. Systems-level Cancer Gene Identification from Protein Interaction Network Topology Applied to Melanogenesis-related Functional Genomics Data. J R Soc Interface, 2009 Jul 22
8. Ho H. Milenkovic T. Memisevic V. Aruri J. Przulj N. Ganesan AK. Protein Interaction Network Topology Uncovers Melanogenesis Regulatory Network Components Within Functional Genomics Datasets. BMC Syst Biol. 2010;4:84. PMCID: 2904735
9. Ho H. Kapadia R. Al-Tahan S. Ahmad S. Ganesan AK. WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. J Biol Chem. 2011; 8;286(14):12509-23.
10. Ho H. Ganesan AK. The Pleiotropic Roles of Autophagy Regulators in Melanogenesis. Pigment Cell Melanoma Res. 2011 Aug;24(4):595-60.
11. Ghasri P. Gattu S. Saedi N. Ganesan A. Chemical leukoderma following application of transdermal methylphenidate patch. J Am Acad Dermatol. 2012 Jun;66(6):e237-8.
12. Ho, H. Aruri, J. Kapadia, R. Mehr, H. White MA. Ganesan AK. RhoJ and Pak Kinases Regulate Melanoma Chemoresistance by Suppressing Pathways that Sense DNA Damage. Cancer Res. 2012 Sep 12.
13. Ho H. Hopkin AS. Kapadia R. Vasudeva P. Schilling J. Ganesan AK. RhoJ Modulates Melanoma Invasion by Altering Actin Cytoskeletal Dynamics. Pigment Cell Melanoma Res. 2012 Dec 18
C. Research Support