UCI is located ten minutes from John Wayne International Airport (SNA) and can be reached from several major freeways.

5 Freeway from Los Angeles: 5 south, to 55 south, to 405 south. Exit at Jamboree Road. Turn right on Jamboree, left on Campus Drive, right on West Peltason Drive. Parking structures are ahead on Mesa.

5 Freeway from San Diego: 5 north to 405 north. Exit at Culver Drive. Turn left on Culver Drive, right on Campus Drive and left on West Peltason Drive. Parking structures are ahead on Mesa.

405 Freeway from Los Angeles: 405 south. Exit at Jamboree Road. Turn right on Jamboree, left on Campus Drive, right on West Peltason Drive. Parking structures are ahead on Mesa.

405 Freeway from San Diego: 405 north. Exit at Culver Drive. Turn left on Culver Drive, right on Campus Drive and left on West Peltason Drive. Parking structures are ahead on Mesa.

91 Freeway: 91 west to 55 south. Merge onto 405.