Developing Physical Insights into Biomolecular Machinery

    We currently perform simulations via COVID-19 HPC Consortium

Bio-molecular machines are reminiscent of life’s fundamental delicacies in molecular design. They are made by nano- to micrometer scale protein complexes with cyclic functional cycles of mechano-chemistry, being able to achieve comparatively high energy efficiency and accuracy, and balance well between functions and constraints in cellular environment and under evolution. Our researches have been focused on revealing physical mechanisms underlying some of these protein complexes and machinery.

​   By utilizing computational biophysics approaches, including a spectrum of molecular modeling and simulation techniques, statistical mechanics, and stochastic methods, we aim at providing insights that would help us to better understand physics of living systems, and also enabling artificial redesign of biomolecular systems for a variety of purposes in bio-medical researches.