UCI Muscle Biology

Inflammation

UCI Muscle Group found a population of KLRG1+ Tem and TemRA were expanded in both the CD4+ and CD8 + T-cell subpopulations in patients withIBM. KLRG1 expression in CD8+ T-cells increased with T-cell differentiation with the lowest levels of expression in Tn and highest in highly differentiated TemRA and CD56+ CD8+ T-cells.

Featured Research

Armando Villalta, PhD
Assistant Professor, Physiology and Biophysics
Inflammation, Duchenne Muscular Dystrophy

**CD8⁺CD56⁺ T Cells in Blood Are KLRG1⁺ and Have the Highest KLRG1 Receptor Density of All CD8 T-Cell Populations**. (A) Frequency of blood CD8+CD56+ T cells among CD3+ T cells. (B) Frequency of blood killer cell lectin-like receptor subfamily G member 1 (KLRG1)+ cells among CD3+CD8+CD56+ T cells. (C) KLRG1 levels in inclusion body myositis (IBM) T-cell subpopulations expressed as the mean fluorescence intensity (MFI).

UCI Muscle Group found a population of KLRG1+ Tem and TemRA were expanded in both the CD4+ and CD8+ T-cell subpopulations in patients with IBM. KLRG1 expression in CD8+ T-cells increased with T-cell differentiation with the lowest levels of expression in Tn and highest in highly differentiated TemRA and CD56+ CD8+ T-cells.

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