The Parsons Lab

 

• 2023 An inducible model of chronic hyperglycemia

    Tucker, T.R., Knitter, C.A., Khoury, D.M., Eshghi, S., Tran, S., Sharrock,        A.V., Wiles, T.J., Ackerley, D.F., Mumm, J.S. and Parsons, M.J.

            Dis Model Mech. 16(8):dmm050215. doi: 10.1242/dmm.050215. 

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• 2021 SOX9 modulates cancer biomarker and cilia genes in pancreatic cancer.
  Edelman HE, McClymont SA, Tucker TR, Pineda S, Beer RL, McCallion AS, Parsons MJ

  Hum Mol Genet. 30:485-499. doi: 10.1093/hmg/ddab064.

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• 2020 Attenuating the EGFR-ERK-SOX9 axis promotes liver progenitor cell-mediated liver regeneration in zebrafish.
  So J, Kim M, Lee SH, Ko S, Lee DA, Park H, Azuma M, Parsons MJ, Prober D, Shin D.

  Hepatology. 2020 Jun 29:10.1002/hep.31437. doi: 10.1002/hep.31437. Online ahead of print.

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• 2017 Endoderm Jagged induces liver and pancreas duct lineage in zebrafish.
  Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng XI, Groff M, Wang K, Parsons MJ, Crump JG, Dong PDS.

  Nature Communications 8(1):769.

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• 2016 Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation.
  Huang W, Beer RL, Delaspre F, Wang G, Edelman HE, Park H, Azuma M, Parsons MJ.

  Developmental Biology 418(1): 28-39.

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• 2016 Centroacinar cells: At the center of pancreas regeneration.
  Beer RL, Parsons MJ, Rovira M.

  Developmental Biology 413(1): 8-15. Front cover.

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• 2015 Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration.
  Delaspre F, Beer RL, Rovira M, Huang W, Wang G, Gee S, Vitery Mdel C, Wheelan SJ, Parsons MJ.

  Diabetes 64(10): 3499-3509.

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• 2015 First quantitative high-throughput screen in zebrafish identifies novel pathways for increasing pancreatic beta-cell mass.
  Wang G, Rajpurohit SK, Delaspre F, Walker SL, White DT, Ceasrine A, Kuruvilla R, Li RJ, Shim JS, Liu JO, Parsons MJ*, Mumm JS*.

  eLife 4:e08261 *Joint work

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• 2015 Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish.
  Wang YJ, Park JT, Parsons MJ, Leach SD

  Developmental Dynamics 244(6): 724-735.

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• 2014 Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey.
  Park JT, Johnson N, Liu S, Levesque M, Wang YJ, Ho H, Huso D, Maitra A, Parsons MJ, Prescott JD, Leach SD.

  Oncogene 34(21): 2801-2806.

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• 2014 Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development.
  Huang W, Wang G, Delaspre F, Vitery Mdel C, Beer RL, Parsons MJ.

  Developmental Biology 394(1): 83-93.

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• 2014 Adoption of the Q transcriptional regulatory system for zebrafish transgenesis.
  Subedi A, Macurak M, Gee ST, Monge E, Goll MG, Potter CJ, Parsons MJ, Halpern ME.

  Methods 66(3): 433-440.

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• 2013 Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas.
  Matsuda H, Parsons MJ, Leach SD.

  PLoS One. 17; 8(9):e74350. doi: 10.1371/journal.pone.0074350.

 

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• 2012 Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration.
  Manfroid I, Ghaye A, Naye F, Detry N, Palm S, Pan L, Ma TP, Huang W, Rovira M, Martial JA, Parsons MJ, Moens CB, Voz ML, Peers B.

  Developmental Biology 366(2): 268-278.

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• 2012 Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish.
  Walker SL, Ariga J, Mathias JR, Coothankandaswamy V, Xie X, Distel M, Köster RW, Parsons MJ, Bhalla KN, Saxena MT, Mumm JS.

  PLoS One 7:e29916.

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• 2011 Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation.
  Rovira M, Huang W, Yusuff S, Shim JS, Ferrante AA, Liu JO, Parsons MJ.

  Proc Natl. Acad Sci USA 108 (48):19264-9.

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• 2011 Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing beta-cells.
  Wang Y, Rovira M, Yusuff S, Parsons MJ.

  Development 138 (4): 609-617.

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• 2009 Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas.
  Parsons MJ, Pisharath H, Yusuff S, Moore JC, Siekmann AF, Lawson N, Leach SD.

  Mechanisms of Development 126(10): 898-912.

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• 2009 Regeneration of the pancreas in adult zebrafish.
  Moss JB, Koustubhan P, Greenman M, Parsons MJ, Walter I, Moss LG.

  Diabetes 58 (8): 1844-1851.

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• 2009 Nitroreductase-mediated cell ablation in transgenic zebrafish embryos.
  Pisharath H, Parsons MJ.

  Book chapter in Zebrafish: Methods and Protocols (Methods in Molecular Biology) 546: 133-143.

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• 2007 Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase.
  Pisharath H, Rhee JM, Swanson MA, Leach SD, Parsons MJ.

  Mechanisms of Development 124(3): 218-227.

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