This paper demonstrates the mechanism how a ubiquitin chain represses transcription factor, and how a switch to a K11-linkage enriched chain releases repression and allows transcription factor activation.
Molecular Cell paper published
CRISPR toolset paper published in JBC
Lin, D.-W., Chung, B.P., Huang, J.-W., Wang, X., Huang, L., and Kaiser, P. (2019). Microhomology based CRISPR tagging tools for protein tracking, purification, and depletion. J. Biol. Chem.
Congratulations to Zane for being named the Stanley Behrens Fellow in Medicine 2019
https://www.som.uci.edu/graduate-studies/features/feature-zane-norman.asp