Dr. Chloe Wang
Ph.D., Southern Medical University, 2017, Epidemiology and Vector Biology
M.Sc., University of California, Irvine, 2018, Biomedical and Translational Science
Ecological Microbiology; Vector Biology; Epidemiology
Biology of dengue vector Aedes albopictus. Aedes albopictus is highly invasive vector species that transmit several arboviruses. Bacteria microbiota may have profound impacts on vector development, reproduction, immunity against pathogens and vectorial capacity. My research examines the role of bacterial microbiota on mosquito survival and vectorial capability.
Surveillance and control of dengue vectors. Aedes aegypti and Ae. albopictus are non-native to California, but establishment of Ae. aegypti was first reported in 2013, and for Ae. albopictus in 2001 and then in 2011. As of now, Ae. aegypti is abundantly distributed in central and Southern California; in contrast, the distribution of Ae. albopictus is more focal and less abundant in southern California. A major question is whether Ae. albopictus will expand its distribution and become more abundant. With the support of PacVec program, in collaboration with local vector control districts in southern California I am testing the hypothesis that Ae. albopictus may expand its distribution range and increase its abundance in southern California as Ae. albopictus has evolved its ability to adapt to urban environments and warm and dry climate conditions. In addition, I am testing the effects of new larvicides on mosquito control.
Epidemiology of malaria. I am interested in developing and evaluation of new malaria diagnosis methods.
Zhong D, Hemming-Schroeder E., Wang X., Kibret S., Zhou, G., Atieli H., Lee MC., Afrane Y.A., Githeko A.K., and Yan, G., 2020. extensive new Anopheles cryptic species involved in human malaria transmission in western Kenya. Scientific Reports. Preprint
Li, Y., Zhou, G., Zhong, S., Wang, X., Zhong, D., Hemming-Schroeder, E., Yi, G., Fu, F., Fu, F., Cui, L. and Cui, G., 2020. Spatial heterogeneity and temporal dynamics of mosquito population density and community structure in Hainan Island, China. Parasites & Vectors, 13(1), pp.1-11.
Chang, X., Zhong, D., Wang, X., Bonizzoni, M., Li, Y., Zhou, G., Cui, L., Wei, X. and Yan, G., 2020. Genomic Variant Analyses in Pyrethroid Resistant and Susceptible Malaria Vector, Anopheles sinensis. G3: Genes, Genomes, Genetics, 10(7), pp.2185-2193.
Zhou, G., Yu, L., Wang, X., Zhong, D., Lee, M.C., Kibret, S. and Yan, G., 2020. Behavioral response of insecticide-resistant mosquitoes against spatial repellent: a modified self-propelled particle model simulation. bioRxiv.
Su, X., Guo, Y., Deng, J., Xu, J., Zhou, G., Zhou, T., Li, Y., Zhong, D., Kong, L., Wang, X. and Liu, M., 2019. Fast emerging insecticide resistance in Aedes albopictus in Guangzhou, China: Alarm to the dengue epidemic. PLoS neglected tropical diseases, 13(9), p.e0007665.
Wang X, Liu T, Wu Y, Zhong D, Zhou G, Su X, Xu J, Sotero CF, Sadruddin AA, Wu K, Chen XG, Yan G. (2018). “Bacterial microbiota assemblage in Aedes albopictus mosquitoes and its impacts on larval development”. Molecular Ecology. 2018 Jul; 27(14):2972-85.
Zhong D, Lo E, Wang X, Yewhalaw D, Zhou G, Atieli HE, Githeko A, Hemming-Schroeder E, Lee MC, Afrane Y, Yan G. (2018). Multiplicity and molecular epidemiology of Plasmodium vivax and Plasmodium falciparum infections in East Africa. Malaria Journal. 17(1):185.
Kahindi SC, Muriu S, Derua YA, Wang X, Zhou G, Lee MC, Mwangangi J, Atieli H, Githeko AK, Yan G. (2018). Efficacy and persistence of long-lasting microbial larvicides against malaria vectors in western Kenya highlands. Parasites & vectors. 11(1):438.
Derua YA, Kahindi SC, Mosha FW, Kweka EJ, Atieli HE, Wang X, Zhou G, Lee MC, Githeko AK, Yan G. (2018). Microbial larvicides for mosquito control: Impact of long lasting formulations of Bacillus thuringiensis var. israelensis and Bacillus sphaericus on non‐target organisms in western Kenya highlands. Ecology and evolution. 8(15):7563-73. https://doi.org/10.1002/ece3.4250
Wang, X., Wu, K., Chen, X., Yan G. (2017). “Advances in assemblages and functions of mosquito-bacteria symbiosis”, Chinese Journal of Parasitology and Parasitic Diseases, 35(3): 305-312.
Wang, X., Zhou, G., Zhong, D., Wang, X., Wang, Y., Yang, Z., Cui, L. and Yan, G. (2016). Life-table studies revealed significant effects of deforestation on the development and survivorship of Anopheles minimus larvae. Parasites & Vectors, 9:323. https://doi.org/10.1186/s13071-016-1611-5
Liu, T., Xu, Y., Wang, X., Gu, J., Yan, G., and Chen, X. G. (2017). Antiviral systems in vector mosquitoes. Developmental & Comparative Immunology https://doi.org/10.1016/j.dci.
Zhong, D., Wang, X., Xu, T., Zhou, G., Wang, Y., Lee, M. C., Hartsel, J.A., Cui, L. and Yan, G. (2016). Effects of microclimate condition changes due to land use and land cover changes on the survivorship of malaria vectors in China-Myanmar border region. PLoS One, 11(5): e0155301. https://doi.org/10.1371/journal.pone.0155301.
Liu, H., Liu, T., Xie, L., Wang, X., Deng, Y., Chen, C.H., James, A.A. and Chen, X.G. and Yan, G. (2016). Functional analysis of Orco and odorant receptors in odor recognition in Aedes albopictus. Parasites & Vectors, 9: 363. https://doi.org/ 10.1186/s13071-016-1644-9
Chang, X., Zhong, D., Lo, E., Fang, Q., Bonizzoni, M., Wang, X., Lee, M., Zhou, G., Zhu, G., Qin, Q., Chen, X., Cui, L. and Yan, G. (2016). Landscape genetic structure and evolutionary genetics of insecticide resistance gene mutations in Anopheles sinensis. Parasites & Vectors, 9: 228. https://doi.org/10.1186/s13071- 016-1513-6
Xu, J., Bonizzoni, M., Zhong, D., Zhou, G., Cai, S., Li, Y., Wang, X., Lo, E., Lee, R., Sheen, R. and Duan, J., Yan G. and Chen, X. (2016). Multi-country Survey Revealed Prevalent and Novel F1534S Mutation in Voltage-Gated Sodium Channel (VGSC) Gene in Aedes albopictus. PLoS Negl Trop Dis, 10: p.e0004696. https://doi.org/10.1371 /journal.pntd.0004696
Zhou, G., Lo, E., Zhong, D., Wang, X., Wang, Y., Malla, S., Lee, M., Yang, Z., Cui, L. and Yan, G. (2016). Impact of interventions on malaria in internally displaced persons along the China–Myanmar border: 2011–2014. Malaria journal, 15: 471. https://doi: 10.1186/s12936-016-1512-2
Zhou, N., Wang, X., Deng, Y., Liu, H., Liu, T., and Chen, X. 2014. “Cloning, identification and preliminary functional analysis of odorant receptor 7 gene of Aedes albopictus.” Journal of Southern Medical University 34, no. 010 (2014): 1420-1425
Past Research Experiences
World Health Organization, Geneva, Switzerland Research Assistant, July-Sept. 2017
- Systematic analysis of impact of insecticide resistance on the effectiveness of insecticides in malaria control.
- WHO Malaria Threat Map buildup
- WHO documents review including Bhutan IRMMP, GVCR brochure, VBD maps, vector control health topic webpage
University of California, Irvine, United States Research Assistant, Jan. 2014-June 2017
- Mosquito bacterial microbiota assemblage and function;
- Molecular and functional characterization of mosquito odorant receptors;
- Formulation of new mosquito larvicides and field testing;
- Ecological and insecticide resistance studies of malaria and dengue vectors.
Honors and Awards
- September 2017, University Scholarship for Professional development Supplemental Tuition ($11,016), UC Irvine.
- January 2014-May 2017, NIH Infectious Disease Research Training Scholarship for International Students, UC Irvine.
- October 2016, Distinguished Ph.D. Student Scholarship, Southern Medical University.
- September 2016, Travel award ($2,500) for Clinical Study Design and Statistics Training workshop sponsored by the National Institutes of Health (NIH), Thailand
- November 2014, Travel award ($1,500) for Gordon Research Conferences-Tropical Infectious Diseases, Galveston, United States.
Funded by PacVec (Pacific Southwest Center of Excellence in Vector-Borne Diseases), 2019. “Larval ecology of invasive Aedes aegypti and Aedes albopictus mosquitoes in southern California”.