2023
Liu, S., Wang, H., Li, X., Zhang, F., Lee, J.K., Li, Z., Yu, C., Hu, J.J., Zhao, X., Suematsu, T., Alvarez-Cabrera, A.L., Liu, Q., Zhang, L., Huang, L., Aphasizheva, I., Aphasizhev, R., Zhou, Z.H. Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science, 2023, Accepted.
Yu, C., Huang, L. New Advances in Cross-linking Mass Spectrometry Toward Structural Systems Biology, Current Opinion in Chemical Biology, 2023, in press
Mandal, K., Wicaksono, G., Yu, C., Adams, J.J., Hoopmann, M.R, Temple, W.C., Izgutdina, A., Escobarm, B.P., Gorelik, M., Ihling, C.H., Nix, M.A., Naik, N., Xie, W., Huebner, J., Rollins, L.A., Reid, S.M., Ramos, E., Kasap, C., Steri, V., Serrano, J.A., Salangsang, F., Phojanakong., P., McMillan, M., Gavallos, V., Leavitt, A.D., Logan, A.C., Rooney, E., Eyquem, J., Sinz, A., Huang, BJ, Stieglitz, E., Smith, C.C., Moritz, R.L., Sidhu, S.S., Huang, L., Wiita, A.P. Structural surfaceomics reveals an AML-specific conformation of Integrin-β2 as a cellular therapy target, Nature Cancer, 2023, Accepted.
Lin, L., Jung, K.M., Lee, H.L., Le, J., Colleluori, G., Wood, C., Palese, F., Squire, E., Ramirez, J., Su, S., Torrens, A., Fotio, Y., Tang, L., Yu, C., Yang, Q., Huang, L., DiPatrizio, N., Jang, C., Cinti, S., Piomelli, D. Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood. Cell Metab. 2023 May 24:S1550-4131(23)00179-1. doi: 10.1016/j.cmet.2023.05.002. Online ahead of print. PMID: 37267956
Jiao, F., Leah, S., Yu, C., Gutierrez, C., Rychnovsky, S., Huang, L. Exploring an Alternative Cysteine-reactive Chemistry to Enable Proteome-wide PPI Analysis by Cross-linking Mass Spectrometry. Anal. Chem. 2023 Jan 31;95(4):2532-2539. doi: 10.1021/acs.analchem.2c04986. Epub 2023 Jan 18. PMID: 36652389
2022
Hu, J.J., Lee, J.K.J., Liu, Y.T., Yu, C., Huang, L., Aphasizheva, I., Aphasizhev, R., Zhou, Z.H. Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase. Structure 2022 Dec 12:S0969-2126(22)00486-5. doi: 10.1016/j.str.2022.11.015. Online ahead of print. PMID: 36543169.
Durairaj, G., Demir, Ö., Lim, B., Baronio, R., Tifrea, D., Hall, L.V., DeForest, J.C., Lauinger, L., Fallatah, M.M., Yu, C., Bae, H., Lin, D., Kim, J.K., Salehi, F., Jang, C., Qiao, F., Lathrop, R.H., Huang, L., Edwards, R., Rychnovsky, S., Amaro, R.E., Kaiser, P. Discovery of compounds that reactivate p53 mutants in vitro and in vivo. Cell Chem Biol. 2022 Sep 15;29(9):1381-1395.e13. doi: 10.1016/j.chembiol.2022.07.003. Epub 2022 Aug 10.
Rawson, S., Walsh, R.M. Jr, Velez, B., Schnell, H.M., Jiao, F., Blickling, M., Ang, J., Bhanu, M.K., Huang, L., Hanna, J. Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Nat Struct Mol Biol. 2022 Aug;29(8):791-800. doi: 10.1038/s41594-022-00808-5. Epub 2022 Aug 4. PMID: 35927584.
Chen, B., Basak, S., Chen, P., Zhang, C., Perry, K., Tian, S., Yu, C., Dong, M., Huang, L., Bowen, M.E., Jin, R. Structure and conformational dynamics of Clostridioides difficile toxin A. Life Science Alliance 2022 March 15; 5(6). doi: 10.26508/lsa.202201383.
Jiao, F., Yu, C., Wheat, A., Wang, X., Rychnovsky, S.D. and Huang, L. Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis. Anal Chem. 2022 March 2. doi: 10.1021/acs.analchem.1c04485. Online ahead of print.
Yu, C., Wang, X., Huang, L. Developing a Targeted Quantitative Strategy for Sulfoxide-Containing MS-Cleavable Cross-Linked Peptides to Probe Conformational Dynamics of Protein Complexes. Anal Chem. 2022 Feb 23. doi: 10.1021/acs.analchem.1c05298. Online ahead of print.
Han, H., Nakaoka, H.J., Hofmann, L., Zhou, J.J., Yu, C., Zeng, L., Nan, J., Seo, G., Vargas, R.E., Yang, B., Qi, R., Bardwell, L., Fishman, D.A,, Cho, K.W.Y., Huang, L., Luo, R., Warrior, R., Wang, W. The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nat Cell Biol. 2022 Jan;24(1):74-87. doi: 10.1038/s41556-021-00813-8. Epub 2022 Jan 13.
Wang, Y., Hu, Y., Höti, N., Huang, L., Zhang, H. Characterization of In Vivo Protein Complexes via Chemical Cross-Linking and Mass Spectrometry. Anal Chem. 2022 Jan 25;94(3):1537-1542. doi: 10.1021/acs.analchem.1c02410. Epub 2021 Dec 28.
2021
Song, A., Hazlett, Z., Abeykoon, D., Dortch, J., Dillon, A., Curtiss, J., Martinez, S.B., Hill, C.P., Yu, C., Huang, L., Fushman, D., Cohen, R.E., Yao, T. Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions. Elife. 2021 Nov 11;10:e72798. doi: 10.7554/eLife.72798. Online ahead of print. PMID: 34761751.
Villamil, M., Xiao, W., Yu, C., Huang, L., Xu, P., Kaiser, P. The Ubiquitin Interacting Motif-Like Domain of Met4 selectively binds K48 Polyubiquitin Chains. Mol Cell Proteomics. 2021 Nov 8;:100175. doi: 10.1016/j.mcpro.2021.100175. [Epub ahead of print] PubMed PMID: 34763062.
Leissing, F., Misch, N.V., Wang, X., Werner, L., Huang, L., Conrath, U., Beckers, G.J.M. Purification of MAP-kinase protein complexes and identification of candidate components by XL-TAP-MS. Plant Physiol. 2021 Sep 21:kiab446. doi: 10.1093/plphys/kiab446. Online ahead of print. PMID: 34609515
Yu, C., Wang, X., Li, W., Liu, Y., Huang, L. Developing a Bimolecular Affinity Purification Strategy to Isolate 26S Proteasome Holocomplexes for Complex-Centric Proteomic Analysis. Anal Chem. 2021 Sep 22. doi: 10.1021/acs.analchem.1c03551. Online ahead of print.
Kaake, R.M., Echeverria, I., Kim, S.J., Von Dollen, J., Chesarino, N.M., Feng, Y., Yu, C., Ta, H., Chelico, L., Huang, L., Gross, J., Sali, A., Krogan, N.J.. Characterization of a A3G-VifHIV-1-CRL5-CBFβ structure using a cross-linking mass spectrometry pipeline for integrative modeling of host-pathogen complexes. Mol Cell Proteomics. 2021 Aug 10:100132. doi: 10.1016/j.mcpro.2021.100132. Online ahead of print. PMID: 34389466.
Wheat, A., Yu, C, Wang, X., Burke, A.M., Chemmama, I.E., Kaake, R.M., Baker, P., Rychnovsky, S.D., Yang, J., Huang, L. Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2023360118. doi: 10.1073/pnas.2023360118.
Cao, Y., Tang, L., Du, K., Paraiso, K., Sun, Q., Liu, Z., Ye, X., Fang, Y., Yuan, F., Chen, Y.H., Chen, Y., Wang, X., Yu, C., Blitz, I.L., Wang, P.H., Huang, L., Cheng, H., Lu, X., Cho, K.W., Seldin, M., Fang, Z., Yang, Q.. Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1. JCI Insight. 2021 Jul 27:147692. doi: 10.1172/jci.insight.147692. Online ahead of print. PMID: 34314389.
Gutierrez, C., Salituro, L.J., Yu, C., Wang, X., DePeter, S.F., Rychnovsky, S.D., Huang, L. Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers. Mol Cell Proteomics. 2021; 20:100084. doi: 10.1016/j.mcpro.2021.100084. PubMed PMID: 33915260; PubMed Central PMCID: PMC8214149.
Wu K, Huynh KQ, Lu I, Moustakim M, Miao H, Yu C, Haeusgen MJ, Hopkins BD, Huang, L., Zheng N, Sanchez R, DeVita RJ, Pan ZQ. Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2007328118. doi: 10.1073/pnas.2007328118.
Chen L, Zhang Y, Shu X, Chen Q, Wei T, Wang H, Wang X, Wu Q, Zhang X, Liu X, Zheng S, Huang, L, Xiao J, Jiang C, Yang B, Wang Z, Guo X. Proteasome regulation by reversible tyrosine phosphorylation at the membrane. Oncogene. 2021 Feb 18. doi: 10.1038/s41388-021-01674-z. Online ahead of print.
Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C.B., Xing, L., Gerhard, R., Huang, L., Dong, M., Jin, R.. Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Nat Commun. 2021 Jun 18;12(1):3748. doi: 10.1038/s41467-021-23878-3.
2020
Hu X, Kim JK, Yu C, Jun HI, Liu J, Sankaran B, Huang, L., Qiao F. Quality-Control Mechanism for Telomerase RNA Folding in the Cell. Cell Rep. 2020 Dec 29;33(13):108568. doi: 10.1016/j.celrep.2020.108568.
Leitner A, Bonvin AMJJ, Borchers CH, Chalkley RJ, Chamot-Rooke J, Combe CW, Cox J, Dong MQ, Fischer L, Götze M, Gozzo FC, Heck AJR, Hoopmann MR, Huang, L., Ishihama Y, Jones AR, Kalisman N, Kohlbacher O, Mechtler K, Moritz RL, Netz E, Novak P, Petrotchenko E, Sali A, Scheltema RA, Schmidt C, Schriemer D, Sinz A, Sobott F, Stengel F, Thalassinos K, Urlaub H, Viner R, Vizcaíno JA, Wilkins MR, Rappsilber J., Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry. Structure. 2020 Nov 3;28(11):1259-1268. doi: 10.1016/j.str.2020.09.011. Epub 2020 Oct 15.
Gao, X., Wang, Q., Wang, Y., Liu, J., Liu, S., Liu, J., Zhou, X., Zhou, L., Chen, H., Pan, L., Chen, J., Wang, D., Zhang, Q., Shen, S., Xiao, Y., Wu, Z., Cheng, Y., Chen, G., Krubra, S., Qin, J., Huang, L., Zhang, P., Wang, C., Moses, R.E., Lonard, D.M., Malley, B.W.O., Fares ,F., Zhang, B., Li, X., Li, L., Xiao, J. The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Nat Commun. 2020 Aug 6;11(1):3904. PMID: 32764536 [PubMed – as supplied by publisher]
Aphasizheva, I., Yu, T., Suematsu, T., Liu, Q., Mesitov, M.V., Yu, C., Huang, L., Zhang, L., Aphasizhev, R. Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei. Nucleic Acids Res. gkaa575, https://doi.org/10.1093/nar/gkaa575, Published: 02 July 2020
Alkafeef, S.S., Lane, S., Yu, C., Zhou, T., Solis, N.V., Filler, S.G., Huang, L., Liu, H. Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes. PLoS Genet. 2020 Jun; 16(6): e1008881. Published online 2020 Jun 11. doi: 10.1371/journal.pgen.1008881 PMCID: PMC7319344
Yu, C., Novitsky, E.J., Cheng, N.W., Rychnovsky, S.D., Huang, L. Exploring Spacer Arm Structures for Designs of Asymmetric Sulfoxide-containing MS-cleavable Cross-linkers. Anal Chem. 2020 Mar 23. doi: 10.1021/acs.analchem.0c00298. [Epub ahead of print]
Zhang, J., Tang, N., Zhao, Y., Zhao, R., Fu, X., Zhao, D., Zhao, Y., Huang, L., Li, C., Qiu, Y., Xue, B., Fang, L. Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice. J Proteome Res. 2020 Apr 3; 19(4): 1788–1799. Published online 2020 Mar 10. doi: 10.1021/acs.jproteome.0c00028 PMCID: PMC7205775
Gutierrez, C., Chemmama, I.E., Mao, H., Yu, C., Echeverria, I., Block, S.A., Rychnovsky, S.D., Zheng, N., Sali, A., Huang, L. Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling. Proc Natl Acad Sci U S A. 2020 Feb 7. pii: 201915542. doi: 10.1073/pnas.1915542117. [Epub ahead of print] (recommended by F1000Prime: https://facultyopinions.com/prime/737338163#eval793571438)
Zhang, J., Zhao, R., Yu, C., Bryant, CLN, Wu, K., Liu, Z., Ding, Y., Zhao, Y., Xue, B., Pan, Z.Q., Li, C*., Huang, L.*, Fang, L*. IKK-mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. J Proteome Res. 2020 Jan 17. doi: 10.1021/acs.jproteome.9b00626. [Epub ahead of print] (*co-correspondence)
Liu, X., Xiao, W., Zhang, Y., Wiley, S.E., Zuo, T., Zheng, Y., Chen, N., Chen, L., Wang, X., Zheng, Y., Huang, L., Lin, S., Murphy, A.N., Dixon, J.E., Xu, P., Guo, X. Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):328-336. doi: 10.1073/pnas.1912531117. Epub 2019 Dec 16.
2019
Yu, C., Wang, X., Huszagh, A.S., Viner, R., Novitsky, E.J., Rychnovsky, S.D., Huang, L. Probing H2O2-mediated Structural Dynamics of the Human 26S Proteasome Using Quantitative Cross-linking Mass Spectrometry (QXL-MS). Mol Cell Proteomics. Mol Cell Proteomics. 2019 May;18(5):954-967. doi: 10.1074/mcp.TIR119.001323. Epub 2019 Feb 5.
Abuin, L., Prieto-Godino, L.L., Pan, H., Gutierrez, C., Huang, L., Jin, R., Benton, R. In vivo assembly and trafficking of olfactory Ionotropic Receptors. BMC Biol. 2019 Apr 17;17(1):34. doi: 10.1186/s12915-019-0651-7.
Mesitov, M.V., Yu, T., Suematsu, T., Sement, F.M., Zhang, L., Yu, C., Huang, L., Aphasizheva, I. Pentatricopeptide repeat poly(A) binding protein KPAF4 stabilizes mitochondrial mRNAs in Trypanosoma brucei. Nat Commun. 2019 Jan 11, 10(1):146. doi: 10.1038/s41467-018-08137-2.
2018
Yu, C., Huang, L., Cross-Linking Mass Spectrometry: An Emerging Technology for Interactomics and Structural Biology. Anal Chem. 2018 Jan 2;90(1):144-165. doi: 10.1021/acs.analchem.7b04431. Epub 2017 Nov 21. PMID: 29160693.
Wang X, Huang L. Dissecting Dynamic and Heterogeneous Proteasome Complexes Using In Vivo Cross-Linking-Assisted Affinity Purification and Mass Spectrometry. Methods Mol Biol. 2018;1844:401-410. doi: 10.1007/978-1-4939-8706-1_25.
Alkafeef, S.S., Yu, C., Huang, L., Liu, H. Wor1 establishes opaque cell fate through inhibition of the general co-repressor Tup1 in Candida albicans. PLoS Genet. 2018 Jan 16;14(1):e1007176. doi: 10.1371/journal.pgen.1007176. eCollection 2018 Jan. PMID: 29337983.
Gutierrez, C., Block, S., Yu, C., Soohoo, S., Huszagh, A., Rychnovsky, S., Huang, L. Developing a Novel Sulfoxide-containing MS-cleavable Homobifunctional Cysteine Reactive Cross-linker for Studying Protein-Protein Interactions. Anal. Chem., 2018, Jun 5. doi: 10.1021/acs.analchem.8b01287. [Epub ahead of print]
Sement, F.M., Suematsu, T., Zhang, L., Yu, T., Huang, L., Aphasizheva, I., Aphasizhev, R. Transcription initiation defines kinetoplast RNA boundaries. Proc Natl Acad Sci U S A. 2018 Oct 17. pii: 201808981. doi: 10.1073/pnas.1808981115. [Epub ahead of print]
2017
Wang, X., Cimermancic, P., Yu, C., Schweitzer, A., Chopra, N., Engel, J.L., Greenberg, C., Huszagh, A.S., Beck, F., Sakata, E., Yang, Y., Novitsky, E.J., Leitner, A., Nanni, P., Kahraman, A., Guo, X., Dixon, J.E., Rychnovsky, S.D., Aebersold, R., Baumeister, W., Sali, A., Huang, L. Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol Cell Proteomics. 2017 May;16(5):840-854. doi: 10.1074/mcp.M116.065326. Epub 2017 Mar 14. (Cover paper for the May 2017 issue of MCP)
Han, J.W., Valdez, J.L., Ho, D.V., Lee, C.S., Kim, H.M., Wang, X., Huang, L., Chan, J.Y. Nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) is regulated by O-GlcNAc transferase. Free Radic Biol Med. 2017 Jun 15;110:196-205. doi: 10.1016/j.freeradbiomed.2017.06.008. [Epub ahead of print].
Zhang, L., Sement, F.M., Suematsu, T., Yu, T., Monti, S., Huang, L., Aphasizhev, R., Aphasizheva, I. PPR polyadenylation factor defines mitochondrial mRNA identity and stability in trypanosomes. EMBO J. 2017 Aug 15;36(16):2435-2454. doi: 10.15252/embj.201796808. Epub 2017 Jul 6.
Gu, Z.C., Wu, E., Sailer, C., Jando, J., Styles, E., Eisenkolb, I., Kuschel, M., Bitschar, K., Wang, X., Huang, L., Vissa, A., Yip, C.M., Yedidi, R., Friesen, H., Enenkel, C. Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast. Mol Biol Cell. 2017 Sep 15;28(19):2479-2491. doi: 10.1091/mbc.E17-03-0162. Epub 2017 Aug 2.
Scott, H., Kim, J.K., Yu, C., Huang, L., Qiao, F., Taylor, D.J. Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex. J Mol Biol. 2017 Sep 15;429(19):2863-2872. doi: 10.1016/j.jmb.2017.08.002. Epub 2017 Aug 12.
Wang, X., Chemmama, I.E., Yu, C., Huszagh, A., Xu, Y., Viner, R., Block, S.A., Cimermancic, P., Rychnovsky, S.D., Ye, Y., Sali, A., Huang, L. The Proteasome-Interacting Ecm29 Protein Disassembles the 26S Proteasome in Response to Oxidative Stress. J Biol Chem. 2017 Sep 29;292(39):16310-16320. doi: 10.1074/jbc.M117.803619. Epub 2017 Aug 15.
Kim, J.K., Liu, J., Hu, X., Yu, C., Roskamp, K., Sankaran, B., Huang, L., Komives, E.A., Qiao, F. Structural Basis for Shelterin Bridge Assembly. Mol Cell. 2017 Nov 16;68(4):698-714.e5. doi: 10.1016/j.molcel.2017.10.032. PMID: 29149597.
Yu, C., Huang, L., Cross-Linking Mass Spectrometry: An Emerging Technology for Interactomics and Structural Biology. Anal Chem. 2018 Jan 2;90(1):144-165. doi: 10.1021/acs.analchem.7b04431. Epub 2017 Nov 21. PMID: 29160693.
2016
Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, Dixon JE. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol. 2016, 18(2):202-12. doi: 10.1038/ncb3289.
Aphasizheva, I., Maslov, D.A., Qian, Y., Huang, L., Wang, Q., Costello, C.E., Aphasizhev, R., Ribosome-associated pentatricopeptide repeat proteins function as translational activators in mitochondria of trypanosomes. Mol Microbiol. 2016 Mar; 99(6):1043-58. doi: 10.1111/mmi.13287. Epub 2016 Jan 20.
Suematsu, T., Zhang, L., Aphasizheva, I., Monti, S., Huang, L., Wang, Q., Costello, C.E., Aphasizhev, R. Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3′ Processome to Generate Guide RNAs. Mol. Cell. 2016 Feb 4;61(3):364-78. doi: 10.1016/j.molcel.2016.01.004. Epub 2016 Jan 28.
Zhang, H.H., Lechuga, T.J., Chen, Y., Yang, Y., Huang, L., Chen, D.B. Quantitative Proteomics Analysis of VEGF-Responsive Endothelial Protein S-Nitrosylation Using Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and LC-MS/MS. Biol Reprod. 2016 May;94(5):114. doi: 10.1095/biolreprod.116.139337. Epub 2016 Apr 13.
Yu, C., Yang, Y., Wang, X., Guan, S., Fang, L., Liu, F., Walters, K.J., Kaiser, P., Huang, L. Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation. Mol Cell Proteomics. 2016 Apr 25. pii: mcp.M116.058271. [Epub ahead of print]
Gutierrez, C.B., Yu, C., Novitsky, E.J., Huszagh, A.S., Rychnovsky, S.D., Huang, L. Developing an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein-Protein Interactions. Anal Chem. 2016 Aug 16; 88(16):8315-22. doi: 10.1021/acs.analchem.6b02240. Epub 2016 Jul 29. (Selected as an ACS Editors’ Choice article)
Fang, L., Chen, D., Yu, C., Li, H., Brocato, J., Huang, L., Jin, C. Mechanisms Underlying Acrolein-mediated Inhibition of Chromatin Assembly. Mol Cell Biol. 2016 Nov 14, 36(23):2995-3008. Print 2016 Dec 1.
Yu C, Huszagh A, Viner R, Novitsky EJ, Rychnovsky SD, Huang L. Developing a Multiplexed Quantitative Cross-Linking Mass Spectrometry Platform for Comparative Structural Analysis of Protein Complexes. Anal Chem. 2016, 88(20):10301-10308. Epub 2016 Sep 27. (It was featured by CE&N 2017)
2015
Burke, A.M., Kandur, W., Novitsky, E.J., Kaake, R.M., Yu, C., Kao, A., Vellucci, D., Huang, L., Rychnovsky, S.D. Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry. Org Biomol Chem. 2015 May 7, 13(17):5030-7. doi: 10.1039/c5ob00488h.
Li, Q., Li, Y., Gu, B., Fang, L., Zhou, P., Bao, S., Huang, L.*, Dai, X*. Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-Mediated Degradation. J. Biol. Chem. 2015 Jul 13. pii: jbc.M115.639419. [Epub ahead of print](*Co-correspondence)
Kandur, W.V., Kao, A., Vellucci, D., Huang, L., Rychnovsky, S.D. Design of CID-cleavable protein cross-linkers: identical mass modifications for simpler sequence analysis. Org Biomol Chem. 2015, 13(38):9793-807. doi: 10.1039/c5ob01410g.
Liu, J., Yu, C., Hu, X., Kim, J., Bierma, J.C., Jun, H., Rychnovsky, S.D., Huang, L., and Qiao, F. Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis. Cell Reports, 2015 Sep 9. pii: S2211-1247(15)00928-6. doi: 10.1016/j.celrep.2015.08.043. [Epub ahead of print]
Lv, Y., Meng, B., Dong, H., Jing, T., Wu, N., Yang, Y., Huang, L., Moses, R.E., O’Malley, B.W., Mei, B., and Li, X. Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice. Neuropsychopharmacology, 2015, Sep 15. doi: 10.1038/npp.2015.285. [Epub ahead of print]
Bilanchone, V., Clemens, K., Kaake, R., Dawson, A.R., Matheos, D., Nagashima, K., Sitlani, P., Patterson, K., Chang, I., Huang, L., Sandmeyer, S. Ty3 Retrotransposon Hijacks Mating Yeast RNA Processing Bodies to Infect New Genomes. PLoS Genet., 2015 Sep 30, 11(9):e1005528. doi: 10.1371/journal.pgen.1005528. eCollection 2015.
Jiang, L., Kosenko, A., Yu, C., Huang, L., Li, X., and Hoshi, N., Activation of m1 muscarinic acetylcholine receptor induces surface transport of KCNQ channel via CRMP-2 mediated pathway. J. Cell. Sci., 2015, Oct 7. pii: jcs.175547.
Yu, C., Mao, H., Novitsky, E.J., Tang, X., Rychnovsky, S., Zheng, N., Huang, L. Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8. Nat Commun. 2015 Dec 3;6:10053. doi: 10.1038/ncomms10053
2014
Kaake, R.M., Kao, A., Yu, C., Huang, L. Characterizing the Dynamics of Proteasome Complexes by Proteomics Approaches. Antioxid Redox Signal. 2014, 21(17):2444-56. doi: 10.1089/ars.2013.5815 (invited review)
Yu, C., Kandur, W., Kao, A., Rychnovsky, S.D., Huang, L. Developing New Isotope-coded MS-cleavable Cross-linkers for Elucidating Protein Structures. Anal Chem. 2014, 86(4):2099-106. doi: 10.1021/ac403636b.
Rezvani, K. Sane, S., Boudreau, D. Gupta, B., Autenried, R., Wang, X., Wang, H., Schlenker, E., Zhang, D., Telleria, C., Huang, L., Chauhan, S., Abdullah, A. Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells. 2014, Cell Death & Disease, 5:e1118. doi: 10.1038/cddis.2014.100.
Satohisa, S., Zhang, H.H., Feng, L., Yang, Y.Y., Huang, L., Chen, D.B. Endogenous NO Upon Estradiol-17β Stimulation and NO Donor Differentially Regulate Mitochondrial S-Nitrosylation in Endothelial Cells. Endocrinology. 2014,155(8):3005-3016.
Chong, C.A., Wu, K., Yang, Y., Lee, C., Nayak, J., Xu, M., Li, J., Brown, B.D., Zhen, Z., Sanchez, R., Huang, L., Pan, Z.Q. A Pivotal Role for the Ubiquitin Y59-E51 Loop in Lysine-48 Polyubiquitination. 2014, Proc. Natl. Acad. Sci. U S A, 111(23):8434-8439.
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2013
Gordon, E.A., Whisenant, T.C., Kaake, R., Zeller, M., Gordon, W.M., Krotee, P., Patel, V., Baldi, P., Huang, L., Bardwell, L. Combining docking site and phosphosite predictions to find new substrates: Identification of Smoothelin-like-2 (SMTNL2) as a c-Jun N-terminal kinase (JNK) substrate. Cell. Signaling, 2013, doi:pii: S0898-6568(13)00231-3. 10.1016/j.cellsig.2013.08.004.