Proton Flash Radiotherapy: Performance Characterization and Optimization of Design Parameters
Developing a Treatment Planning System and Monte Carlo analysis pipeline for Bragg Peak FLASH radiotherapy and assessing alignment sensitivities for 3D range modulator designs
Team Members:
Hailey Matyac (Team Lead), Loren Grace Kinoshita, and Sara Safaei
Project Deliverables:
- Monte Carlo parameter sweep analysis using a server with millions of simulated particles
- Treatment Planning Dose rate studies for a liver tumor patient and a brain tumor patient
- 3D Range modulator manufactured and verified
References:
- [1] Simeonov, Yuri, et al. “3D range-modulator for scanned particle therapy: Development, Monte Carlo Simulations and experimental evaluation.” Physics in Medicine & Biology, vol. 62, no. 17, 2017, pp. 7075–7096, https://doi.org/10.1088/1361-6560/aa81f4.
- [2] Maryland Proton, “Proton Therapy with Varian ProBeam,” YouTube, Feb. 18, 2022. https://www.youtube.com/watch?v=sI909_nRKM8&t=146s (accessed Jun. 03, 2024).
- [3] Low, D A et al. “A technique for the quantitative evaluation of dose distributions.” Medical physics vol. 25,5 (1998): 656-61. doi:10.1118/1.598248
