We invite you to the first Fall 2014 Photonics@UCI seminar series ‘Frontiers in Photonics’ in association with the Beckman Laser Institute, UCI.
Intraoperative guidance with intrinsic near infrared imaging
Dr. Anita Mahadevan-Jansen
Department of Biomedical Engineering, Vanderbilt University
12:00-1:00 pm, Wednesday, October 15th, 2014
Location: Beckman Laser Institute library (direction: http://www.bli.uci.edu/directions.php)
Lunch will be provided!
Abstract:
For endocrine diseases where surgery is the only curative option, the success of procedures depends on complete resection of benign and malignant parathyroid or thyroid tissue during the time of surgery. Complications arise because the surgeon relies on visual inspection and professional experience during surgery to identify the parathyroid glands, which are small and variable in location. Inadvertent injury to or removal of the parathyroid during such procedures is the leading reason for litigation amongst endocrine surgeons. We have developed near infrared autofluroescence spectroscopy for the intraoperative identification of the parathyroid gland. Our current goal is to provide real time feedback to the surgeon by translating this technology into the imaging domain.
The basis for the fluorescence detected in the parathyroid is a novel, unidentified NIR biological fluorophore that is excited at 785 nm with peak emission at 822 nm and the presence of which has previously remained unreported. In a more recent development in our laboratory, we have observed similar fluorescence in normal skeletal muscle that surround soft tissue sarcomas and this has formed the basis for another project where we combine near infrared autofluorescence with Raman spectroscopy for the intraoperative assessment of margins in soft tissue sarcomas. Results this far from both these projects will be presented with the goal towards potential clinical translation.
Bio:
Dr Mahadevan-Jansen develops applications of optical techniques for detection of pathology. Her primary research at the Vanderbilt Biomedical Photonics Laboratories, is to investigate the applications of optical spectroscopies and imaging for cancer diagnosis and guidance of therapy. She received her bachelor’s and master’s degrees in Physics from the University of Bombay, India, and a master’s and PhD degrees in Biomedical Engineering from the University of Texas at Austin. She joined the Vanderbilt engineering faculty in 1996. She is currently the Orrin H. Ingram Professor of Biomedical Engineering at Vanderbilt University and holds a secondary appointment in the Department of Neurological Surgery. Dr Mahadevan-Jansen is an associate editor of Neurophotonics as well as Applied Spectroscopy and serves as a reviewer of more than 20 journals and as chair of numerous professional conferences. She has authored over 75 peer-reviewed publications and is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), and the International Society for Optical Engineering (SPIE).