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Louis’ paper in press @ JoVE: Time-lapse Imaging of Bacterial Swarms and the Collective Stress Response

https://www.jove.com/video/60915/time-lapse-imaging-bacterial-swarms-collective-stress

Summary: We detail a simple method to produce high-resolution time-lapse movies of Pseudomonas aeruginosa swarms that respond to bacteriophage (phage) and antibiotic stress using a flatbed document scanner. This procedure is a fast and simple method for monitoring swarming dynamics and may be adapted to study the motility and growth of other bacterial species

Now @mBio: Kumar’s paper on metabolic dynamics in bacterial biofilms

https://mbio.asm.org/content/11/2/e02730-18.abstract

The rise of antibiotic resistance requires the development of new strategies to combat bacterial infection and pathogenesis. A major direction has been the development of drugs that broadly target virulence. However, few targets have been identified due to the species-specific nature of many virulence regulators. The lack of a virulence regulator that is conserved across species has presented a further challenge to the development of therapeutics. Here, we identify that NADH activity has an important role in the induction of virulence in the pathogen P. aeruginosa. This finding, coupled with the ubiquity of NADH in bacterial pathogens, opens up the possibility of targeting enzymes that process NADH as a potential broad antivirulence approach.

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